Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 7/20 | 0.33 |
| ▸ | CA1 | P00915 | 7/20 | 0.33 |
| ▸ | CA2 | P00918 | 7/20 | 0.33 |
| ▸ | CA9 | Q16790 | 7/20 | 0.33 |
| ▸ | CA7 | P43166 | 4/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5077477 | 1.00 | TSHR (0.48) | TSHRHCAR2SMN1; SMN2CA12CA1 | |
| SCHEMBL9999821 | 1.00 | TSHR (0.48) | TSHRHCAR2SMN1; SMN2CA12CA1 | |
| Bromide SCHEMBL28560064 | 0.97 | TSHR (0.46) | TSHRHCAR2SMN1; SMN2CA12CA1 | |
| SCHEMBL28965299 | 0.88 | TSHR (0.53) | TSHRHCAR2SMN1; SMN2CA12CA1 | |
| SCHEMBL22267735 | 0.80 | SMN1; SMN2 (0.33) | TSHRHCAR2SMN1; SMN2ABCB1 | |
| SCHEMBL8019158 | 0.80 | TSHR (0.46) | TSHRHCAR2CA12CA1CA2 | |
| SCHEMBL8272086 | 0.78 | TSHR (0.43) | TSHRHCAR2CA12CA1CA2 | |
| SCHEMBL22236616 | 0.78 | TSHR (0.43) | TSHRHCAR2CA12CA1CA2 | |
| SCHEMBL2246643 | 0.78 | TSHR (0.43) | TSHRHCAR2CA12CA1CA2 | |
| SCHEMBL19798081 | 0.78 | SMN1; SMN2 (0.32) | TSHRHCAR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180022763-A1 | Anti-Viral Compounds | ABBVIE INC. (US) | 2018-01-25 | — | — | US | disclosed |
| US-9676797-B2 | Anti-viral compounds | ABBVIE INC. (US) | 2017-06-13 | — | — | US | disclosed |
| US-20170057981-A1 | Anti-Viral Compounds | ABBVIE INC. (US) | 2017-03-02 | — | — | US | disclosed |
| US-20160083413-A1 | 2'-CHLORO NUCLEOSIDE ANALOGS FOR HCV INFECTION | IDENIX PHARMACEUTICALS LLC | 2016-03-24 | — | — | US | disclosed |
| US-20160002281-A1 | D-AMINO ACID COMPOUNDS FOR LIVER DISEASE | UNIVERSITE DE MONTPELLIER (FR) | 2016-01-07 | — | — | US | disclosed |
| US-9186440-B2 | Polyester implantable medical device with controlled in vivo biodegradability | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2015-11-17 | — | — | US | disclosed |
| US-20140364575-A1 | POLYESTER IMPLANTABLE MEDICAL DEVICE WITH CONTROLLED IN VIVO BIODEGRADABILITY | ABBOTT CARDIOVASCULAR SYSTEMS (US) | 2014-12-11 | — | — | US | disclosed |
| US-8802126-B2 | Polyester implantable medical device with controlled in vivo biodegradability | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2014-08-12 | — | — | US | disclosed |
| WO-2014058801-A1 | 2'-CHLORO NUCLEOSIDE ANALOGS FOR HCV INFECTION | IDENIX PHARMACEUTICALS, INC. (US) | 2014-04-17 | — | — | WO | disclosed |
| WO-2013177219-A1 | D-AMINO ACID COMPOUNDS FOR LIVER DISEASE | IDENIX PHARMACEUTICALS, INC. (US) | 2013-11-28 | — | — | WO | disclosed |
| US-8323678-B2 | Implantable medical devices comprising poly[l-lactide-co-(3,6-dialkyl-1,4-dioxane-2,5-dione)] | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2012-12-04 | — | — | US | disclosed |
| WO-2012040127-A1 | SUBSTITUTED NUCLEOTIDE ANALOGS | ALIOS BIOPHARMA, INC. (US) | 2012-03-29 | — | — | WO | disclosed |
| US-20110270387-A1 | Implantable Medical Devices Comprising Poly[L-Lactide-Co-(3,6-Dialkyl-1,4-Dioxane-2,5-Dione)] | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2011-11-03 | — | — | US | disclosed |
| US-20090324670-A1 | Polyester Implantable Medical Device With Controlled In Vivo Biodegradability | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170057981-A1 | Anti-Viral Compounds | HAVCR2, EIF2AK2, MAVS | TSHR 4851/4885HCAR2 4551/4885SMN1; SMN2 4259/4885 |
| US-20090324670-A1 | Polyester Implantable Medical Device With Controlled In Vivo Biodegradability | MIF, PDE8A, PDE8B | TSHR 3709/4885HCAR2 1040/4885SMN1; SMN2 4582/4885 |
| US-20160083413-A1 | 2'-CHLORO NUCLEOSIDE ANALOGS FOR HCV INFECTION | SLC28A2, SLC28A1, SLC29A2 | TSHR 4702/4885HCAR2 4483/4885SMN1; SMN2 312/4885 |
| US-20180022763-A1 | Anti-Viral Compounds | HAVCR2, EIF2AK2, MAVS | TSHR 4851/4885HCAR2 4551/4885SMN1; SMN2 4259/4885 |
| US-20160002281-A1 | D-AMINO ACID COMPOUNDS FOR LIVER DISEASE | AADAT, BCAT1, BCAT2 | TSHR 4546/4885HCAR2 2683/4885SMN1; SMN2 2178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.