Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.44 |
| ▸ | VEGFA | P15692 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | GPR4 | P46093 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL114519 | 0.88 | VEGFA (0.50) | GPR119VEGFAEGLN1CHRM2CHRM4 | |
| SCHEMBL14190954 | 0.87 | GPR4 (0.47) | GPR119VEGFAEGLN1ACKR3CHRM2 | |
| SCHEMBL3708001 | 0.84 | HTR2A (0.52) | CHRM2CHRM4CHRM1CHRM3PLK1 | |
| SCHEMBL116110 | 0.83 | GPR119 (0.47) | GPR119 | |
| SCHEMBL113688 | 0.83 | GPR119 (0.47) | GPR119 | |
| SCHEMBL6822757 | 0.81 | VEGFA (0.45) | VEGFAEGLN1ACKR3CHRM2CHRM4 | |
| SCHEMBL116524 | 0.81 | GPR119 (0.41) | GPR119ACKR3CHRM2CHRM4CHRM1 | |
| SCHEMBL2850833 | 0.80 | KDM1A (0.48) | GPR119VEGFAEGLN1ACKR3CHRM2 | |
| SCHEMBL4572803 | 0.79 | SIGMAR1 (0.48) | VEGFAEGLN1ACKR3CHRM2CHRM4 | |
| SCHEMBL22800905 | 0.79 | SIGMAR1 (0.48) | VEGFAEGLN1ACKR3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |