SCHEMBL6823049

SCHEMBL6823049

O=C(O)c1ccc2c(c1)C1(OC2=O)c2cc(Cl)c(O)c(Cl)c2Oc2c1cc(Cl)c(O)c2Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RECQL P46063 4/20 0.43
TDP1 Q9NUW8 4/20 0.43
THRB P10828 3/20 0.43
MEN1 O00255 3/20 0.43
BLM P54132 3/20 0.43
KMT2A Q03164 3/20 0.43
ACE2 Q9BYF1 2/20 0.43
PRMT1 Q99873 2/20 0.43
USP2 O75604 1/20 0.43
CDK2 P24941 1/20 0.43
CHAT P28329 1/20 0.43
BLVRB P30043 1/20 0.43
RXFP1 Q9HBX9 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
GAA P10253 1/20 0.42
PKM P14618 1/20 0.42
GNG2 P59768 1/20 0.41
GNB1 P62873 1/20 0.41
DHFR P00374 1/20 0.38
TYMS P04818 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL203192 0.91 GNG2 (0.43) RECQLTDP1THRBMEN1BLM
SCHEMBL202849 0.90 RECQL (0.42) RECQLTDP1THRBMEN1BLM
SCHEMBL3390818 0.89 TDP1 (0.41) RECQLTDP1THRBMEN1BLM
SCHEMBL16118 0.86 MEN1 (0.39) RECQLTDP1THRBMEN1BLM
SCHEMBL29838713 0.86 MEN1 (0.39) RECQLTDP1THRBMEN1BLM
SCHEMBL29353753 0.86 MEN1 (0.39) RECQLTDP1THRBMEN1BLM
SCHEMBL29401708 0.85 GNG2 (0.50) RECQLTDP1THRBMEN1BLM
SCHEMBL15019692 0.85 GNG2 (0.50) RECQLTDP1THRBMEN1BLM
SCHEMBL6415591 0.83 MEN1 (0.34) RECQLTDP1THRBMEN1BLM
SCHEMBL29486978 0.83 MEN1 (0.61) RECQLTDP1THRBMEN1BLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210292818-A1 DDAO Compounds as Fluorescent Reference Standards LIFE TECHNOLOGIES CORP (US) 2021-09-23 US disclosed
US-10988798-B2 DDAO compounds as fluorescent reference standards Life Technologies Corporation (US) 2021-04-27 US disclosed
US-20190119732-A1 DDAO Compounds as Fluorescent Reference Standards Life Technologies Corporation (US) 2019-04-25 US disclosed
US-10131936-B2 DDAO compounds as fluorescent reference standards Life Technologies Corporation (US) 2018-11-20 US disclosed
US-9790544-B2 DDAO compounds as fluorescent reference standards Life Technologies Corporation (US) 2017-10-17 US disclosed
US-20160258004-A1 DDAO COMPOUNDS AS FLUORESCENT REFERENCE STANDARDS Life Technologies Corporation 2016-09-08 US disclosed
US-9315859-B2 DDAO compounds as fluorescent reference standards Life Technologies Corporation (US) 2016-04-19 US disclosed
EP-2913408-A1 DDAO COMPOUNDS AS FLUORESCENT REFERENCE STANDARDS Life Technologies Corporation (US) 2015-09-02 EP disclosed
EP-2658998-B1 DDAO COMPOUNDS AS FLUORESCENT REFERENCE STANDARDS LIFE TECHNOLOGIES CORP (US) 2015-04-22 EP disclosed
US-20140134615-A1 DDAO Compounds as Fluorescent Reference Standards Life Technologies Corporation (US) 2014-05-15 US disclosed
EP-2658998-A1 DDAO COMPOUNDS AS FLUORESCENT REFERENCE STANDARDS Life Technologies Corporation (US) 2013-11-06 EP disclosed
WO-2012092403-A1 DDAO COMPOUNDS AS FLUORESCENT REFERENCE STANDARDS Life Technologies Corporation (US) 2012-07-05 WO disclosed
US-20120171684-A1 DDAO COMPOUNDS AS FLUORESCENT REFERENCE STANDARDS Life Technologies Corporation (US) 2012-07-05 US disclosed
EP-0978569-B1 METHOD OF DNA SEQUENCING RIKAGAKU KENKYUSHO (JP) 2004-09-22 EP disclosed
US-6482938-B1 Compounds having energy transfer function and method for DNA base sequencing by using the same WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) 2002-11-19 US disclosed
US-6365350-B1 REACTING RIBONUCLEOTIDE 5'-TRIPHOSPHATES AND 3'-DEOXY NUCLEOTIDE TRIPHOSPHATES WITH RNA POLYMERASE AND DNA FRAGMENT CONTAINING A PROMOTER SEQUENCE FOR THE POLYMERASE, THEN SEPARATING THE TRANSCRIPTION PRODUCT AND SEQUENCING IT THE INSTITUTE OF PHYSICAL AND CHEMICAL RESEARCH (JP) 2002-04-02 US disclosed
US-6265569-B1 HAS ALKYL LINKER INCLUDING DOUBLE OR TRIPLE BOND WHICH ATTACHES FLUORESCENT MOLECULE TO NUCLEOTIDE; FOR TERMINATORS IN DNA SEQUENCING USING RNA POLYMERASES THE INSTITUTE OF PHYSICAL AND CHEMICAL RESEARCH (JP) 2001-07-24 US disclosed
EP-1046648-A1 3'-DEOXYRIBONUCLEOTIDE DERIVATIVES THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH (JP) 2000-10-25 EP disclosed
EP-0978569-A1 METHOD OF DNA SEQUENCING THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH (JP) 2000-02-09 EP disclosed
EP-0967219-A1 COMPOUNDS HAVING ENERGY TRANSFER FUNCTION AND METHOD FOR DNA BASE SEQUENCING BY USING THE SAME THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH (JP) 1999-12-29 EP disclosed