Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 13/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823211 | 0.84 | ULK1 (0.46) | — | |
| SCHEMBL6820542 | 0.83 | SYK (0.36) | IGF1RAXL | |
| SCHEMBL6823194 | 0.81 | NPY5R (0.46) | — | |
| SCHEMBL3762160 | 0.81 | IGF1R (0.41) | IGF1RNEK1EGFRBTK | |
| SCHEMBL6819632 | 0.80 | ULK1 (0.38) | — | |
| SCHEMBL6820543 | 0.79 | NTRK1 (0.39) | EGFR | |
| SCHEMBL6820537 | 0.78 | ULK1 (0.35) | — | |
| SCHEMBL6820767 | 0.78 | AURKA (0.35) | IGF1RAXLPTK2 | |
| SCHEMBL6819621 | 0.77 | NTRK1 (0.39) | IGF1R | |
| SCHEMBL6819540 | 0.77 | IRAK4 (0.32) | IGF1RPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004037814-A1 | INDAZOLINONE COMPOSITIONS USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-06 | — | — | WO | disclosed |