Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CTSV | O60911 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5594949 | 0.94 | HTR1A (0.53) | HTR1AADRA1DADRA1AADRA1BGPR35 | |
| SCHEMBL6823290 | 0.86 | MAOB (0.49) | HTR1AADRA1DADRA1AADRA1BAPP | |
| SCHEMBL2305236 | 0.81 | NPC1 (0.68) | HTR1AADRA1DADRA1AADRA1BPOLB | |
| SCHEMBL30015078 | 0.81 | NPC1 (0.68) | HTR1AADRA1DADRA1AADRA1BPOLB | |
| SCHEMBL27911893 | 0.80 | GPR35 (0.53) | GPR35NPC1RAB9AMEN1KMT2A | |
| SCHEMBL30318898 | 0.80 | HPD (0.49) | HTR1AADRA1DADRA1AADRA1BAPP | |
| SCHEMBL3088462 | 0.80 | HTR1A (0.50) | HTR1AADRA1DADRA1AADRA1BGPR35 | |
| SCHEMBL1121791 | 0.80 | HPD (0.49) | HTR1AADRA1DADRA1AADRA1BAPP | |
| SCHEMBL6356278 | 0.79 | MAPT (0.60) | HTR1AADRA1DADRA1AADRA1BAPP | |
| SCHEMBL130119 | 0.79 | APP (0.72) | HTR1AADRA1DADRA1AADRA1BAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |