Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.35 |
| ▸ | STK17B | O94768 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823437 | 0.94 | TSHR (0.41) | LMNAPPARGPPARDPPARAMTNR1A | |
| SCHEMBL6422310 | 0.84 | MTNR1A (0.36) | LMNAMTNR1ASTK17BTSHRKCNA3 | |
| SCHEMBL6426238 | 0.83 | KCNA3 (0.37) | LMNAL3MBTL1MTNR1ASTK17BKCNA3 | |
| SCHEMBL6826208 | 0.82 | F2RL3 (0.41) | L3MBTL1STK17BPRKCA | |
| SCHEMBL6820565 | 0.82 | KCNA3 (0.36) | LMNAL3MBTL1MTNR1ASTK17BKCNA3 | |
| SCHEMBL6820552 | 0.79 | STK17B (0.35) | MTNR1ASTK17BKCNA3PRKCA | |
| SCHEMBL6826721 | 0.78 | MEN1 (0.45) | LMNATSHRMEN1KMT2ANPSR1 | |
| SCHEMBL7347057 | 0.75 | STK17B (0.33) | STK17BMEN1KMT2A | |
| SCHEMBL7353733 | 0.75 | MAOB (0.43) | LMNAL3MBTL1STK17BLTB4RLTB4R2 | |
| SCHEMBL6421954 | 0.75 | ALDH1A1 (0.41) | L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004076444-A2 | NOVEL HYDROXYCOUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-10 | — | — | WO | disclosed |