Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.55 |
| ▸ | FLT3 | P36888 | 9/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.55 |
| ▸ | CDK2 | P24941 | 5/20 | 0.55 |
| ▸ | CDK1 | P06493 | 3/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6821513 | 0.99 | CTSL (0.58) | CTSLADORA3ADORA1FLT3PDGFRA | |
| SCHEMBL5193703 | 0.92 | ADORA3 (0.53) | CTSLADORA3ADORA1FLT3PDGFRA | |
| SCHEMBL6817879 | 0.89 | CTSL (0.70) | CTSLADORA3ADORA1FLT3CDK1 | |
| SCHEMBL6820572 | 0.88 | CTSL (0.72) | CTSLADORA3ADORA1FLT3PDGFRA | |
| SCHEMBL6817663 | 0.88 | CTSL (0.72) | CTSLADORA3ADORA1FLT3PDGFRA | |
| SCHEMBL8204168 | 0.88 | CTSL (0.72) | CTSLADORA3ADORA1FLT3PDGFRA | |
| SCHEMBL6817790 | 0.88 | CTSL (0.58) | CTSLADORA3ADORA1FLT3PDGFRA | |
| SCHEMBL8110131 | 0.88 | CTSL (0.72) | CTSLADORA3ADORA1FLT3PDGFRA | |
| SCHEMBL6947217 | 0.88 | CTSL (0.72) | CTSLADORA3ADORA1FLT3PDGFRA | |
| SCHEMBL6820593 | 0.87 | CTSL (0.66) | CTSLADORA3ADORA1FLT3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056745-B1 | 6,9-DISUBSTITUTED 2- TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | AVENTIS PHARMA INC (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6413974-B1 | INHIBITORS OF CYCLIN DEPENDENT KINASES, PARTICULARLY CDK-2; PREVENTING APOPTOSIS IN NEURONAL CELLS; ANTINEOPLASTIC AGENTS; NEURONAL INJURY AND DEGENERATION; CEREBROVASCULAR DISEASE | AVENTIS PHARMACEUTICALS INC. | 2002-07-02 | — | — | US | disclosed |