SCHEMBL6824702

SCHEMBL6824702

C=CCC(C#N)(C#N)Cc1ccccc1Cl

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.40
IDO1 P14902 3/20 0.37
PNMT P11086 1/20 0.37
TAAR1 Q96RJ0 3/20 0.35
PYCR1 P32322 1/20 0.33
PKM P14618 1/20 0.33
HPGD P15428 2/20 0.32
TRPA1 O75762 1/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
CHRM2 P08172 1/20 0.32
KMT2A Q03164 1/20 0.32
GRIN1 Q05586 1/20 0.31
GRIN2B Q13224 1/20 0.31
CYP1A2 P05177 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6825165 0.87 PNMT (0.42) ALDH1A1IDO1PNMTTAAR1HPGD
SCHEMBL6825198 0.81 TAAR1 (0.33) ALDH1A1TAAR1HPGDKMT2A
SCHEMBL6824615 0.81 GGPS1 (0.43) ALDH1A1IDO1PYCR1HPGDNPC1
SCHEMBL6835194 0.77 MRGPRX4 (0.41) ALDH1A1
SCHEMBL6826870 0.76 KMT2A (0.42) ALDH1A1IDO1TAAR1CHRM2KMT2A
SCHEMBL4657492 0.75 IDO1 (0.36) ALDH1A1IDO1PNMTTAAR1PYCR1
SCHEMBL6824706 0.74 CXCR2 (0.32)
SCHEMBL6821483 0.72 SLC6A4 (0.40) ALDH1A1IDO1TAAR1HPGDKMT2A
SCHEMBL6827102 0.72 FDPS (0.41) IDO1PNMTTAAR1PYCR1
SCHEMBL6821416 0.71 PNMT (0.41) ALDH1A1IDO1PNMTTAAR1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040142821-A1 Pesticide composition comprising malononitrile compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-07-22 US disclosed
EP-1385377-A1 PESTICIDE COMPOSITION COMPRISING MALONONITRILE COMPOUNDS SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2004-02-04 EP disclosed
WO-2002089579-A1 PESTICIDE COMPOSITION COMPRISING MALONONITRILE COMPOUNDS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-11-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040142821-A1 Pesticide composition comprising malononitrile compounds CBR1, CBR3, ME1 ALDH1A1 867/4885IDO1 389/4885PNMT 1108/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.