SCHEMBL6825071

SCHEMBL6825071

N#CC(C#N)CCc1ccc(OC(F)(F)F)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.41
SLC6A4 P31645 5/20 0.40
GPR84 Q9NQS5 1/20 0.40
SLC6A3 Q01959 4/20 0.39
ALDH1A1 P00352 3/20 0.39
TSHR P16473 2/20 0.39
MAPT P10636 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
SCN9A Q15858 2/20 0.39
MEN1 O00255 1/20 0.39
TP53 P04637 1/20 0.39
CYP3A4 P08684 1/20 0.39
ALOX15 P16050 1/20 0.39
BLM P54132 1/20 0.39
KMT2A Q03164 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
HIF1A Q16665 1/20 0.39
HSD17B10 Q99714 1/20 0.39
EPAS1 Q99814 1/20 0.39
ACACB O00763 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4656296 0.83 ACACB (0.45) DAOSLC6A4ALDH1A1TSHRMAPT
SCHEMBL4714751 0.77 PDE4A (0.46) DAOSLC6A4GPR84SLC6A3ALDH1A1
SCHEMBL19043747 0.77 SLC6A4 (0.46) DAOSLC6A4GPR84SLC6A3ALDH1A1
SCHEMBL6820492 0.77 TAAR1 (0.50) DAOMEN1KMT2A
Iodide SCHEMBL30828284 0.75 ALDH1A1 (0.42) DAOSLC6A4ALDH1A1TSHRMAPT
SCHEMBL6826508 0.75 ACACB (0.45) SLC6A4SLC6A3ALDH1A1TSHRMAPT
SCHEMBL28658281 0.75 SLC6A4 (0.44) DAOSLC6A4GPR84SLC6A3ALDH1A1
Acetonitrile SCHEMBL28224520 0.73 SLC6A4 (0.43) DAOSLC6A4GPR84SLC6A3ALDH1A1
SCHEMBL549086 0.73 ALDH1A1 (0.44) DAOSLC6A4ALDH1A1TSHRMAPT
Iodide SCHEMBL29202228 0.73 TAAR1 (0.53) DAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1385817-A2 MALONONITRILE COMPOUNDS AND THEIR USE AS PESTICIDES SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2004-02-04 EP disclosed
EP-1385377-A1 PESTICIDE COMPOSITION COMPRISING MALONONITRILE COMPOUNDS SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2004-02-04 EP disclosed
WO-2002090320-A2 MALONONITRILE COMPOUNDS AND THEIR USE AS PESTICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-11-14 WO disclosed
WO-2002089579-A1 PESTICIDE COMPOSITION COMPRISING MALONONITRILE COMPOUNDS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-11-14 WO disclosed