Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11503302 | 0.80 | MPO (0.57) | SIGMAR1CES1MPOG6PC1CYP2A6 | |
| SCHEMBL28424372 | 0.80 | SIGMAR1 (0.46) | SIGMAR1CES1MPOG6PC1CYP2A6 | |
| SCHEMBL29446311 | 0.80 | SIGMAR1 (0.46) | SIGMAR1CES1MPOG6PC1CYP2A6 | |
| SCHEMBL5489164 | 0.80 | SIGMAR1 (0.46) | SIGMAR1CES1MPOG6PC1CYP2A6 | |
| SCHEMBL9379776 | 0.80 | SIGMAR1 (0.46) | SIGMAR1CES1MPOG6PC1CYP2A6 | |
| SCHEMBL7837577 | 0.80 | SIGMAR1 (0.46) | SIGMAR1CES1MPOG6PC1CYP2A6 | |
| Hydrochloric Acid SCHEMBL10649574 | 0.78 | SIGMAR1 (0.44) | SIGMAR1CES1MPOG6PC1CYP2A6 | |
| Hydrochloric Acid SCHEMBL15053825 | 0.78 | SIGMAR1 (0.44) | SIGMAR1CES1MPOG6PC1CYP2A6 | |
| SCHEMBL10395522 | 0.77 | SIGMAR1 (0.47) | SIGMAR1CES1MPOG6PC1CYP2A6 | |
| SCHEMBL9235448 | 0.77 | SIGMAR1 (0.50) | SIGMAR1CES1MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028110-B1 | NOVEL DIHYDRONAPHTHALENE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME | DAIICHI SEIYAKU CO (JP) | 2004-04-14 | — | — | EP | disclosed |
| CN-1117732-C | Novel dihydronaphthalene compound and process and producing the same | DAIICHI SEIYAKU CO (JP) | 2003-08-13 | — | — | CN | disclosed |
| US-6559157-B2 | Excellent 17 alpha - hydroxylase/C17-20-lyase and aromatase inhibiting activity, thromboxan A2 synthesis inhibiting activity, useful as preventive and/or therapeutic agents for various male and female sex hormone dependent diseases | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-05-06 | — | — | US | disclosed |
| US-20020032211-A1 | Novel dihydronaphthalene compounds and processes of producing the same | DAIICHI PHARMACEUTICALS CO., LTD. (JP) | 2002-03-14 | — | — | US | disclosed |
| CN-1268120-A | Novel dihydronaphthalene compound and process and producing the same | YUKIJIRUSHI NYUGYO KABUSHIKI K (JP) | 2000-09-27 | — | — | CN | disclosed |
| EP-1028110-A1 | NOVEL DIHYDRONAPHTHALENE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME | Yukijirushi Nyugyo Kabushiki Kaisha (JP) | 2000-08-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032211-A1 | Novel dihydronaphthalene compounds and processes of producing the same | CYP19A1, HSD17B11, CYP17A1 | SIGMAR1 4364/4885CES1 361/4885MPO 435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.