Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPP1CA | P62136 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014985 | 0.82 | KMT2A (0.71) | PPP1CAKMT2AALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL6827214 | 0.76 | PIN1 (0.46) | PPP1CAKMT2AALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL6823721 | 0.75 | L3MBTL1 (0.56) | PPP1CAKMT2AALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL6827194 | 0.74 | MAPT (0.47) | PPP1CAKMT2AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL6827155 | 0.74 | MEN1 (0.44) | PPP1CAKMT2AALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL7108352 | 0.73 | MAPT (0.53) | PPP1CAKMT2AALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL7106274 | 0.72 | MAPT (0.67) | PPP1CAKMT2AALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL19563690 | 0.72 | L3MBTL1 (0.56) | PPP1CAKMT2AALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL6827047 | 0.72 | KMT2A (0.47) | PPP1CAKMT2AALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL10036934 | 0.71 | PPP1CA (0.49) | PPP1CAKMT2AALDH1A1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004054988-A1 | ARYLTHIOETHERPYRIMIDINE AND ARYLOXYETHERPYRIMIDINE DERIVATIVES AND THEIR THERAPEUTIC USES | ACTIVE PASS PHARMACEUTICALS, INC. (CA) | 2004-07-01 | — | — | WO | claimed |
| WO-2004054988-A1 | ARYLTHIOETHERPYRIMIDINE AND ARYLOXYETHERPYRIMIDINE DERIVATIVES AND THEIR THERAPEUTIC USES | ACTIVE PASS PHARMACEUTICALS, INC. (CA) | 2004-07-01 | — | — | WO | disclosed |