Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 7/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823721 | 0.82 | L3MBTL1 (0.56) | MEN1KMT2APPP1CAL3MBTL1POLB | |
| SCHEMBL6827047 | 0.81 | KMT2A (0.47) | MEN1KMT2APPP1CAL3MBTL1POLB | |
| SCHEMBL6826997 | 0.74 | PPP1CA (0.65) | MEN1KMT2APPP1CAL3MBTL1POLB | |
| SCHEMBL9122113 | 0.73 | KMT2A (0.50) | MEN1KMT2AL3MBTL1POLBCYP2C9 | |
| SCHEMBL6827214 | 0.72 | PIN1 (0.46) | MEN1KMT2APPP1CAL3MBTL1POLB | |
| SCHEMBL5862483 | 0.70 | HTR2A (0.54) | HTR2ASLC6A4KCNH2 | |
| SCHEMBL31287771 | 0.66 | HSP90AA1 (0.57) | MEN1KMT2AHTR2ASLC6A4KCNH2 | |
| SCHEMBL11175966 | 0.66 | HSP90AA1 (0.57) | MEN1KMT2AHTR2ASLC6A4KCNH2 | |
| SCHEMBL30672829 | 0.66 | PIN1 (0.51) | MEN1KMT2APPP1CAL3MBTL1POLB | |
| SCHEMBL16391122 | 0.66 | PIN1 (0.51) | MEN1KMT2APPP1CAL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004054988-A1 | ARYLTHIOETHERPYRIMIDINE AND ARYLOXYETHERPYRIMIDINE DERIVATIVES AND THEIR THERAPEUTIC USES | ACTIVE PASS PHARMACEUTICALS, INC. (CA) | 2004-07-01 | — | — | WO | claimed |
| WO-2004054988-A1 | ARYLTHIOETHERPYRIMIDINE AND ARYLOXYETHERPYRIMIDINE DERIVATIVES AND THEIR THERAPEUTIC USES | ACTIVE PASS PHARMACEUTICALS, INC. (CA) | 2004-07-01 | — | — | WO | disclosed |