Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31144992 | 0.76 | KCNH3 (0.50) | SMN1; SMN2HTTLMNAMAPK1TSHR | |
| SCHEMBL13115771 | 0.75 | ADRA2A (0.55) | SMN1; SMN2HTTLMNAMAPK1TSHR | |
| SCHEMBL22191398 | 0.73 | ALDH1A1 (0.57) | SMN1; SMN2LMNAALDH1A1HPGDMEN1 | |
| SCHEMBL10966604 | 0.72 | ALDH1A1 (0.62) | SMN1; SMN2HTTLMNAMAPK1ALDH1A1 | |
| SCHEMBL22191568 | 0.70 | KCNH3 (0.51) | SMN1; SMN2HTTLMNAMAPK1TSHR | |
| SCHEMBL23362392 | 0.70 | HTT (0.48) | SMN1; SMN2HTTLMNAMAPK1TSHR | |
| SCHEMBL16381665 | 0.70 | STIM1 (0.43) | SMN1; SMN2LMNAALDH1A1HPGDMEN1 | |
| SCHEMBL5944684 | 0.70 | POLB (0.42) | SMN1; SMN2HTTLMNAMAPK1TSHR | |
| SCHEMBL308835 | 0.69 | TPH1 (0.52) | SMN1; SMN2ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL20119731 | 0.68 | SMN1; SMN2 (0.46) | SMN1; SMN2HTTLMNAMAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004085409-A2 | COMPOUNDS AND LIBRARIES OF PYRIDINES, PYRAZINES, IMIDAZO[1,2-A]PYRAZINES AND 1H-IMIDAZO[4,5-B]PYRAZIN-2-ONES AND FIRST AND SECOND MEDICAL USES THEREOF | BIOFOCUS DISCOVERY LTD (GB) | 2004-10-07 | — | — | WO | disclosed |