Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SCN4A | P35499 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 9/20 | 0.38 |
| ▸ | NPC1 | O15118 | 8/20 | 0.38 |
| ▸ | LMNA | P02545 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.36 |
| ▸ | RELA | Q04206 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24805051 | 0.66 | TSHR (0.62) | TSHRRAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL659214 | 0.60 | TSHR (0.71) | TSHRRAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL24026375 | 0.60 | PARP1 (0.67) | TSHRRAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL211172 | 0.60 | TSHR (0.53) | TSHRRAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL11220484 | 0.59 | TSHR (0.65) | TSHRRAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL24741297 | 0.59 | RAB9A (0.45) | TSHRRAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL13278295 | 0.58 | TSHR (0.64) | TSHRRAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL16622749 | 0.58 | — | — | |
| SCHEMBL6515708 | 0.58 | — | — | |
| SCHEMBL15555619 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441719-A1 | N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003037327-A1 | N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | F. HOFFMANN-LA-ROCHE AG (CH) | 2003-05-08 | — | — | WO | disclosed |