Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | MLYCD | O95822 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2059899 | 0.71 | MAOB (0.38) | CYP3A4CYP2D6MAOBSLC6A2SLC6A4 | |
| SCHEMBL28640840 | 0.69 | MEN1 (0.38) | CYP3A4CYP2D6MAOBSLC6A2SLC6A4 | |
| SCHEMBL6828600 | 0.69 | MLYCD (0.38) | CYP2D6MLYCDSLC6A2SLC6A4TP53 | |
| SCHEMBL1336550 | 0.68 | SLC6A2 (0.47) | SLC6A2SLC6A4TP53MAPT | |
| SCHEMBL22594507 | 0.64 | SLC6A2 (0.37) | CYP3A4SLC6A2SLC6A4TP53MAPT | |
| SCHEMBL94821 | 0.64 | MEN1 (0.44) | SLC6A2SLC6A4TP53MAPT | |
| SCHEMBL11160653 | 0.64 | MEN1 (0.44) | SLC6A2SLC6A4TP53MAPT | |
| SCHEMBL4689599 | 0.62 | LMNA (0.38) | CYP3A4CYP2D6MAOBSLC6A2SLC6A4 | |
| SCHEMBL10964311 | 0.62 | SLC6A2 (0.33) | CYP3A4CYP2D6MAOBSLC6A2SLC6A4 | |
| SCHEMBL4692790 | 0.61 | CYP2D6 (0.36) | CYP3A4CYP2D6MAOBSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425270-A2 | METHODS AND INTERMEDIATES FOR PREPARING 4-AMINOQUINOLINE CETP INHIBITORS | Pfizer Products Inc. (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2002088085-A2 | METHODS AND INTERMEDIATES FOR PREPARING 4-AMINOQUINOLINE CETP INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-11-07 | — | — | WO | disclosed |