Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6825783 | 0.88 | ADORA1 (0.56) | ADORA2AADORA3ALDH1A1MAPTTSHR | |
| SCHEMBL6830910 | 0.86 | ALDH1A1 (0.46) | ADORA2AADORA3ALDH1A1MAPTKDM4E | |
| SCHEMBL6828505 | 0.85 | ADORA2A (0.54) | ADORA2AADORA3ALDH1A1MAPTADORA1 | |
| SCHEMBL6828357 | 0.83 | ADORA2A (0.51) | ADORA2AADORA3RAB9AMAPTNPC1 | |
| SCHEMBL6830218 | 0.83 | ALDH1A1 (0.43) | ADORA2AALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL6828670 | 0.83 | XIAP (0.44) | ADORA2AADORA3ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6826020 | 0.83 | NPC1 (0.48) | ADORA2AADORA3RAB9AALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6828860 | 0.82 | ALDH1A1 (0.47) | ADORA2ARAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6830646 | 0.82 | ADORA2A (0.53) | ADORA2ARAB9AALDH1A1MAPTKDM4E | |
| SCHEMBL6828729 | 0.82 | ADORA1 (0.57) | ADORA2AADORA3RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |