Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.53 |
| ▸ | XIAP | P98170 | 3/20 | 0.46 |
| ▸ | GSK3A | P49840 | 5/20 | 0.44 |
| ▸ | GSK3B | P49841 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6825783 | 0.85 | ADORA1 (0.56) | ADORA2AADORA1XIAPMEN1KMT2A | |
| SCHEMBL6828357 | 0.84 | ADORA2A (0.51) | ADORA2AADORA1XIAPKMT2AMAPT | |
| SCHEMBL6825903 | 0.83 | HPGD (0.47) | ADORA2AADORA1XIAPMEN1KMT2A | |
| SCHEMBL6830337 | 0.83 | ADORA2A (0.50) | ADORA2AADORA1XIAPKMT2AALDH1A1 | |
| SCHEMBL6828670 | 0.83 | XIAP (0.44) | ADORA2AADORA1XIAPMEN1KMT2A | |
| SCHEMBL6830910 | 0.83 | ALDH1A1 (0.46) | ADORA2AADORA1XIAPKMT2AALDH1A1 | |
| SCHEMBL6828483 | 0.83 | XIAP (0.44) | ADORA2AADORA1XIAPALDH1A1MAPT | |
| SCHEMBL6826020 | 0.83 | NPC1 (0.48) | ADORA2AADORA1XIAPKMT2AALDH1A1 | |
| SCHEMBL6828830 | 0.82 | ADORA2A (0.48) | ADORA2AADORA1XIAPMEN1KMT2A | |
| SCHEMBL6828894 | 0.81 | SMN1; SMN2 (0.44) | ADORA2AADORA1XIAPALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |