Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 10/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6828483 | 0.88 | XIAP (0.44) | ADORA3ADORA2AADORA1RAB9ANPSR1 | |
| SCHEMBL6828894 | 0.87 | SMN1; SMN2 (0.44) | ADORA3ADORA2AADORA1RAB9ANPSR1 | |
| SCHEMBL6828729 | 0.86 | ADORA1 (0.57) | ADORA3ADORA2AADORA1RAB9ALMNA | |
| SCHEMBL6828357 | 0.84 | ADORA2A (0.51) | ADORA3ADORA2AADORA1RAB9ANPSR1 | |
| SCHEMBL6830337 | 0.83 | ADORA2A (0.50) | ADORA3ADORA2AADORA1RAB9ALMNA | |
| SCHEMBL6826020 | 0.83 | NPC1 (0.48) | ADORA3ADORA2AADORA1RAB9ANPSR1 | |
| SCHEMBL6828670 | 0.81 | XIAP (0.44) | ADORA3ADORA2AADORA1NPSR1LMNA | |
| SCHEMBL6830646 | 0.81 | ADORA2A (0.53) | ADORA2AADORA1RAB9ALMNANPC1 | |
| SCHEMBL6825783 | 0.81 | ADORA1 (0.56) | ADORA3ADORA2AADORA1MAPTALDH1A1 | |
| SCHEMBL2753998 | 0.81 | NPC1 (0.65) | ADORA3ADORA2AADORA1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |