SCHEMBL6829285

SCHEMBL6829285

O=Cc1ccc(COc2ccc(C(F)(F)F)cc2)s1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 7/20 0.44
PTPN1 P18031 1/20 0.41
MRGPRX4 Q96LA9 1/20 0.40
ALDH1A1 P00352 1/20 0.39
HRH3 Q9Y5N1 1/20 0.39
PPARD Q03181 2/20 0.39
PPARA Q07869 2/20 0.39
AOC3 Q16853 1/20 0.38
MAPT P10636 3/20 0.38
L3MBTL1 Q9Y468 3/20 0.38
LMNA P02545 2/20 0.38
MEN1 O00255 1/20 0.38
GAA P10253 1/20 0.38
HTT P42858 1/20 0.38
KMT2A Q03164 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
POLB P06746 2/20 0.38
RAB9A P51151 1/20 0.38
ATM Q13315 1/20 0.38
PPARG P37231 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7126366 0.83 L3MBTL1 (0.43) MAOBPTPN1ALDH1A1MAPTL3MBTL1
SCHEMBL6828965 0.80 MAOB (0.40) MAOBMRGPRX4ALDH1A1HRH3PPARA
SCHEMBL6920177 0.77 NPC1 (0.40) MAOBAOC3RAB9A
SCHEMBL18626699 0.74 CA1 (0.38) ALDH1A1
SCHEMBL7134471 0.73 DAO (0.43) MAOBMRGPRX4ALDH1A1HRH3MAPT
SCHEMBL18002002 0.72 POLB (0.46) MAOBMRGPRX4PPARDPPARAMAPT
SCHEMBL7130916 0.72 MAPT (0.39) ALDH1A1MAPTL3MBTL1POLB
SCHEMBL18002480 0.72 SRD5A2 (0.52) MAOBPPARDPPARAMAPTPOLB
SCHEMBL864810 0.71 MAOB (0.64) MAOBPTPN1MRGPRX4HRH3RAB9A
SCHEMBL6919445 0.71 MAOB (0.44) MAOBPTPN1MRGPRX4ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004037808-A1 2 - SUBSTITUTED HETEROCYCLIC COMPOUNDS AND ANTITUMOR COMPOSITION COMPRISING THE SAME CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2004-05-06 WO disclosed