SCHEMBL6920177

SCHEMBL6920177

O=Cc1ccc(COc2ccc(F)c(F)c2)s1

nearest known ligand 0.40

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.40
RAB9A P51151 2/20 0.40
MAOB P27338 7/20 0.38
AOC3 Q16853 1/20 0.38
MAOA P21397 6/20 0.37
ACHE P22303 1/20 0.37
TDP1 Q9NUW8 1/20 0.35
PRKDC P78527 1/20 0.34
GRM5 P41594 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7126366 0.83 L3MBTL1 (0.43) NPC1RAB9AMAOBMAOA
SCHEMBL7134471 0.79 DAO (0.43) NPC1RAB9AMAOBMAOATDP1
SCHEMBL6828965 0.77 MAOB (0.40) NPC1RAB9AMAOBMAOATDP1
SCHEMBL6829285 0.77 MAOB (0.44) RAB9AMAOBAOC3
SCHEMBL6828913 0.75 MAOB (0.49) NPC1RAB9AMAOBTDP1
SCHEMBL7131180 0.75 MAOB (0.51) NPC1RAB9AMAOBMAOATDP1
SCHEMBL7130916 0.75 MAPT (0.39) TDP1
SCHEMBL18002479 0.73 MAOB (0.49) RAB9AMAOBMAOAACHE
SCHEMBL7131595 0.72 MRGPRX4 (0.57) NPC1RAB9AMAOBMAOA
SCHEMBL28187890 0.71 MAOB (0.57) NPC1RAB9AMAOBMAOAACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004037808-A1 2 - SUBSTITUTED HETEROCYCLIC COMPOUNDS AND ANTITUMOR COMPOSITION COMPRISING THE SAME CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2004-05-06 WO disclosed