Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.52 |
| ▸ | RAB9A | P51151 | 10/20 | 0.52 |
| ▸ | MEN1 | O00255 | 10/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | GPR3 | P46089 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.43 |
| ▸ | RELA | Q04206 | 3/20 | 0.43 |
| ▸ | MAOB | P27338 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19135547 | 0.79 | GPR3 (0.52) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL28479943 | 0.77 | MAPT (0.52) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL6503590 | 0.76 | GPR3 (0.55) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL26737371 | 0.76 | GPR3 (0.55) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL11768220 | 0.73 | GPR3 (0.50) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL28540289 | 0.73 | GPR3 (0.50) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL10745045 | 0.73 | KDM4E (0.52) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL3093060 | 0.73 | GPR3 (0.50) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL28383390 | 0.73 | KDM4E (0.52) | MAPTRAB9AMEN1KMT2ANPC1 | |
| Dibenzothiophene SCHEMBL28979299 | 0.72 | GPR3 (0.93) | MAPTRAB9AMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347963-B1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2004-08-25 | — | — | EP | disclosed |
| EP-1347963-A2 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-01 | — | — | EP | disclosed |
| US-6433005-B1 | SELECTIVE COX II INHIBITOR | SYNTEX (U.S.A.) LLC | 2002-08-13 | — | — | US | disclosed |
| US-20020107280-A1 | NEW BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS | SYNTEX (U.S.A.) LLC | 2002-08-08 | — | — | US | disclosed |
| WO-2002046178-A2 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-13 | — | — | WO | disclosed |
| US-4621091-A | 5-LIPOXYGENASE INHIBITORS; USEFUL IN TREATMENT OF INFLAMMATION, PAIN AND FEVER | MERCK & CO., INC. (US) | 1986-11-04 | — | — | US | disclosed |
| US-4621091-A | 5-LIPOXYGENASE INHIBITORS; USEFUL IN TREATMENT OF INFLAMMATION, PAIN AND FEVER | MERCK & CO., INC. (US) | 1986-11-04 | — | — | US | disclosed |
| EP-0177927-A1 | 3-Hydroxybenzo[b]thiophene-2-sulfide derivatives as specific-5-lipoxygenase inhibitors | MERCK & CO. INC. (US) | 1986-04-16 | — | — | EP | disclosed |
| EP-0177927-A1 | 3-Hydroxybenzo[b]thiophene-2-sulfide derivatives as specific-5-lipoxygenase inhibitors | MERCK & CO. INC. (US) | 1986-04-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020107280-A1 | NEW BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS | SULT1E1, SULT2A1, SULT1A1 | MAPT 2655/4885RAB9A 4769/4885MEN1 4829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.