Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 10/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.52 |
| ▸ | PIP5K1C | O60331 | 7/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.49 |
| ▸ | PIP5K1B | O14986 | 2/20 | 0.49 |
| ▸ | PIP5K1A | Q99755 | 2/20 | 0.49 |
| ▸ | BUB1 | O43683 | 2/20 | 0.49 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.45 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | PI4KA | P42356 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505288 | 0.90 | BUB1 (0.49) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL5813702 | 0.90 | MAPK10 (0.51) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL5813438 | 0.90 | MAPK10 (0.51) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL5814740 | 0.85 | MAPK10 (0.49) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL6830651 | 0.85 | MAPK10 (0.52) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL5814782 | 0.81 | MAPK10 (0.52) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL1519020 | 0.81 | MAPK10 (0.76) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL1518930 | 0.70 | MAPK10 (1.00) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL1518824 | 0.70 | PIP5K1C (0.68) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL1518956 | 0.70 | MAPK10 (0.78) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004052880-A1 | PYRIDINE DERIVATIVES AS JNK INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-06-24 | — | — | WO | claimed |
| WO-2004052880-A1 | PYRIDINE DERIVATIVES AS JNK INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-06-24 | — | — | WO | disclosed |