Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 10/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.52 |
| ▸ | CDK9 | P50750 | 3/20 | 0.43 |
| ▸ | BUB1 | O43683 | 3/20 | 0.41 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6830651 | 0.95 | MAPK10 (0.52) | MAPK10MAPK14MAPK8BUB1PIP5K1C | |
| SCHEMBL5813702 | 0.91 | MAPK10 (0.51) | MAPK10MAPK14MAPK8CDK9BUB1 | |
| SCHEMBL5813438 | 0.91 | MAPK10 (0.51) | MAPK10MAPK14MAPK8CDK9BUB1 | |
| SCHEMBL1518802 | 0.82 | MAPK10 (0.69) | MAPK10MAPK14MAPK8CDK9BUB1 | |
| SCHEMBL6830052 | 0.81 | MAPK10 (0.54) | MAPK10MAPK14MAPK8BUB1PIP5K1C | |
| SCHEMBL1518733 | 0.77 | MAPK10 (0.72) | MAPK10MAPK14MAPK8CDK9BUB1 | |
| SCHEMBL5814740 | 0.74 | MAPK10 (0.49) | MAPK10MAPK14MAPK8BUB1PIP5K1C | |
| SCHEMBL6505288 | 0.71 | BUB1 (0.49) | MAPK10MAPK14MAPK8BUB1PIP5K1C | |
| SCHEMBL6826851 | 0.69 | MAPK10 (1.00) | MAPK10MAPK14MAPK8BUB1PIP5K1C | |
| SCHEMBL1518782 | 0.69 | MAPK10 (1.00) | MAPK10MAPK14MAPK8BUB1PIP5K1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004052880-A1 | PYRIDINE DERIVATIVES AS JNK INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-06-24 | — | — | WO | claimed |
| WO-2006104983-A1 | THERAPEUTIC METHODS FOR TYPE I DIABETES | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL (US) | 2006-10-05 | — | — | WO | disclosed |
| WO-2004052880-A1 | PYRIDINE DERIVATIVES AS JNK INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-06-24 | — | — | WO | disclosed |