Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BUB1 | O43683 | 3/20 | 0.49 |
| ▸ | PIP5K1C | O60331 | 11/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.48 |
| ▸ | PIP5K1B | O14986 | 3/20 | 0.45 |
| ▸ | PIP5K1A | Q99755 | 3/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.45 |
| ▸ | PI4KA | P42356 | 2/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.45 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6830052 | 0.90 | MAPK10 (0.54) | BUB1PIP5K1CPIK3CAPIP5K1BPIP5K1A | |
| SCHEMBL5813702 | 0.80 | MAPK10 (0.51) | BUB1PIP5K1CPIK3CAPIP5K1BPIP5K1A | |
| SCHEMBL5813438 | 0.80 | MAPK10 (0.51) | BUB1PIP5K1CPIK3CAPIP5K1BPIP5K1A | |
| SCHEMBL6830651 | 0.75 | MAPK10 (0.52) | BUB1PIP5K1CPIK3CAMAPK8MAPK10 | |
| SCHEMBL5814740 | 0.75 | MAPK10 (0.49) | BUB1PIP5K1CPIK3CAPIP5K1BPIP5K1A | |
| SCHEMBL1519020 | 0.72 | MAPK10 (0.76) | PIP5K1CPIK3CAPIP5K1BPIP5K1APIK3CD | |
| SCHEMBL5814782 | 0.71 | MAPK10 (0.52) | BUB1PIP5K1CPIK3CAMAPK8MAPK10 | |
| SCHEMBL6505284 | 0.69 | MAPK10 (0.88) | PIP5K1CPIK3CAPIP5K1BPIP5K1APIK3CD | |
| SCHEMBL6507708 | 0.66 | PIP5K1C (0.63) | PIP5K1CPIK3CAPIP5K1BPIP5K1APIK3CD | |
| SCHEMBL17631671 | 0.65 | USP30 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003123-A1 | NOVEL PYRIDINE DERIVATIVES AS JNK SPECIFIC INHIBITORS | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | claimed |
| WO-2005003123-A1 | NOVEL PYRIDINE DERIVATIVES AS JNK SPECIFIC INHIBITORS | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |