Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 12/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 10/20 | 0.52 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | BUB1 | O43683 | 2/20 | 0.41 |
| ▸ | PRKCI | P41743 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5814782 | 0.95 | MAPK10 (0.52) | MAPK10MAPK14MAPK8PIP5K1CPIK3CA | |
| SCHEMBL5813702 | 0.86 | MAPK10 (0.51) | MAPK10MAPK14MAPK8PIP5K1CPIK3CA | |
| SCHEMBL5813438 | 0.86 | MAPK10 (0.51) | MAPK10MAPK14MAPK8PIP5K1CPIK3CA | |
| SCHEMBL6830052 | 0.85 | MAPK10 (0.54) | MAPK10MAPK14MAPK8PIP5K1CPIK3CA | |
| SCHEMBL1518733 | 0.81 | MAPK10 (0.72) | MAPK10MAPK14MAPK8PIP5K1CPIK3CA | |
| SCHEMBL1518802 | 0.77 | MAPK10 (0.69) | MAPK10MAPK14MAPK8PIP5K1CPIK3CA | |
| SCHEMBL6505288 | 0.75 | BUB1 (0.49) | MAPK10MAPK14MAPK8PIP5K1CPIK3CA | |
| SCHEMBL5814740 | 0.74 | MAPK10 (0.49) | MAPK10MAPK14MAPK8PIP5K1CPIK3CA | |
| SCHEMBL17631644 | 0.70 | CDK9 (0.40) | PRKCIGSK3B | |
| SCHEMBL1518968 | 0.69 | MAPK10 (1.00) | MAPK10MAPK14MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004052880-A1 | PYRIDINE DERIVATIVES AS JNK INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-06-24 | — | — | WO | disclosed |