Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6831945 | 0.89 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL6830324 | 0.88 | PTGS2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL6829777 | 0.88 | PTGS2 (0.45) | PTGS2PTGS1 | |
| SCHEMBL6830914 | 0.86 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL6827195 | 0.85 | PTGS2 (0.61) | PTGS2PTGS1ESR1 | |
| SCHEMBL6827093 | 0.82 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL6829923 | 0.79 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL6829774 | 0.77 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL6826942 | 0.77 | PTGS2 (0.53) | PTGS2PTGS1ESR1 | |
| SCHEMBL6827048 | 0.76 | PTGS2 (0.48) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347963-B1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2004-08-25 | — | — | EP | claimed |
| EP-1347963-A2 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-01 | — | — | EP | claimed |
| US-6433005-B1 | SELECTIVE COX II INHIBITOR | SYNTEX (U.S.A.) LLC | 2002-08-13 | — | — | US | claimed |
| US-20020107280-A1 | NEW BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS | SYNTEX (U.S.A.) LLC | 2002-08-08 | — | — | US | claimed |
| WO-2002046178-A2 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-13 | — | — | WO | claimed |
| EP-1347963-B1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2004-08-25 | — | — | EP | disclosed |
| US-6433005-B1 | SELECTIVE COX II INHIBITOR | SYNTEX (U.S.A.) LLC | 2002-08-13 | — | — | US | disclosed |
| US-20020107280-A1 | NEW BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS | SYNTEX (U.S.A.) LLC | 2002-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020107280-A1 | NEW BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS | SULT1E1, SULT2A1, SULT1A1 | PTGS2 6/4885PTGS1 8/4885ESR1 1379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.