Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6830324 | 0.89 | PTGS2 (0.46) | PTGS2PTGS1PTGDR2MEN1KMT2A | |
| SCHEMBL6830307 | 0.89 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL6829777 | 0.89 | PTGS2 (0.45) | PTGS2PTGS1PTGDR2KMT2ALMNA | |
| SCHEMBL6830914 | 0.87 | PTGS2 (0.55) | PTGS2PTGS1MEN1ALDH1A1KMT2A | |
| SCHEMBL6829923 | 0.80 | PTGS2 (0.47) | PTGS2PTGS1MEN1ALDH1A1KMT2A | |
| SCHEMBL6829774 | 0.78 | PTGS2 (0.61) | PTGS2PTGS1ALDH1A1KMT2AHPGD | |
| SCHEMBL6827093 | 0.78 | PTGS2 (0.47) | PTGS2PTGS1MEN1KMT2ARXFP1 | |
| SCHEMBL6827195 | 0.77 | PTGS2 (0.61) | PTGS2PTGS1PTGDR2 | |
| SCHEMBL6827048 | 0.77 | PTGS2 (0.48) | PTGS2PTGS1PTGDR2MEN1KMT2A | |
| SCHEMBL6827028 | 0.76 | PTGS2 (0.44) | PTGS2PTGS1MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347963-B1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2004-08-25 | — | — | EP | disclosed |
| US-6433005-B1 | SELECTIVE COX II INHIBITOR | SYNTEX (U.S.A.) LLC | 2002-08-13 | — | — | US | disclosed |
| US-20020107280-A1 | NEW BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS | SYNTEX (U.S.A.) LLC | 2002-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020107280-A1 | NEW BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS | SULT1E1, SULT2A1, SULT1A1 | PTGS2 6/4885PTGS1 8/4885PTGDR2 278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.