SCHEMBL6830664

SCHEMBL6830664

N#Cc1ccc(NC(=O)c2noc3cc(Cl)ccc23)c(C(=O)O)c1

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 4/20 0.44
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CA7 P43166 1/20 0.43
CA9 Q16790 1/20 0.43
ALB P02768 1/20 0.42
SERPINE1 P05121 5/20 0.41
KDM4E B2RXH2 1/20 0.41
HSD17B10 Q99714 1/20 0.41
AKR1C4 P17516 1/20 0.41
AKR1C3 P42330 1/20 0.41
AKR1C2 P52895 1/20 0.41
AKR1C1 Q04828 1/20 0.41
ABCC9 O60706 2/20 0.40
PPARG P37231 1/20 0.40
PPARA Q07869 1/20 0.40
F10 P00742 1/20 0.40
TMPRSS4 Q9NRS4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6821929 0.89 ALB (0.43) HIF1AALBAKR1C4AKR1C3AKR1C2
SCHEMBL6814011 0.89 ACLY (0.38) HIF1ACA12CA1CA2CA7
SCHEMBL6830641 0.88 AKR1C2 (0.43) HIF1AALBKDM4EAKR1C4AKR1C3
SCHEMBL6813915 0.88 ALB (0.42) HIF1AALB
SCHEMBL6830490 0.86 HIF1A (0.55) HIF1AALB
SCHEMBL6833104 0.86 HIF1A (0.49) HIF1AALBSERPINE1
SCHEMBL6832994 0.85 HIF1A (0.46) HIF1ACA12CA1CA2CA7
SCHEMBL6833190 0.85 HIF1A (0.47) HIF1ACA12CA1CA2CA7
SCHEMBL6818222 0.84 ALB (0.48) HIF1ACA12CA1CA2CA7
SCHEMBL6818795 0.83 CA12 (0.43) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040110802-A1 Antibacterial benzoic acid derivatives PHARMACIA & UPJOHN COMPANY 2004-06-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040110802-A1 Antibacterial benzoic acid derivatives GABRD, GABBR1, GABRA1 HIF1A 220/4885CA12 3776/4885CA1 2993/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.