Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 6/20 | 0.47 |
| ▸ | FAAH | O00519 | 3/20 | 0.39 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 3/20 | 0.38 |
| ▸ | CES1 | P23141 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | PPARD | Q03181 | 3/20 | 0.37 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6829879 | 0.98 | DNM1 (0.49) | DNM1FAAHPAOXMEN1KMT2A | |
| SCHEMBL16913010 | 0.98 | DNM1 (0.49) | DNM1FAAHPAOXMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL30596838 | 0.95 | DNM1 (0.46) | DNM1FAAHPAOXMEN1KMT2A | |
| SCHEMBL27647689 | 0.86 | CES2 (0.50) | FAAHMEN1KMT2ATP53CYP1A2 | |
| SCHEMBL3467535 | 0.86 | CES2 (0.50) | FAAHMEN1KMT2ATP53CYP1A2 | |
| SCHEMBL4085870 | 0.86 | CES2 (0.50) | FAAHMEN1KMT2ATP53CYP1A2 | |
| SCHEMBL27988309 | 0.86 | CES2 (0.50) | FAAHMEN1KMT2ATP53CYP1A2 | |
| SCHEMBL3466717 | 0.86 | CES2 (0.50) | FAAHMEN1KMT2ATP53CYP1A2 | |
| SCHEMBL250174 | 0.86 | CES2 (0.50) | FAAHMEN1KMT2ATP53CYP1A2 | |
| SCHEMBL10592271 | 0.84 | CES2 (0.48) | FAAHMEN1KMT2ATP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6822061-B2 | FOR USE AS FLUID LOSS CONTROL | HALLIBURTON ENERGY SERVICES, INC. | 2004-11-23 | — | — | US | claimed |
| US-6743288-B2 | FLUID LOSS CONTROL AGENT ACRYLIC TERPOLYMERS | HALLIBURTON ENERGY SERVICES, INC. | 2004-06-01 | — | — | US | claimed |
| US-20030096945-A1 | Well cement additives, compositions and methods | EOFF LARRY S (US) | 2003-05-22 | — | — | US | claimed |
| US-20030094122-A1 | Well cement additives, compositions and methods | EOFF LARRY S (US) | 2003-05-22 | — | — | US | claimed |
| US-6822061-B2 | FOR USE AS FLUID LOSS CONTROL | HALLIBURTON ENERGY SERVICES, INC. | 2004-11-23 | — | — | US | disclosed |
| US-6743288-B2 | FLUID LOSS CONTROL AGENT ACRYLIC TERPOLYMERS | HALLIBURTON ENERGY SERVICES, INC. | 2004-06-01 | — | — | US | disclosed |
| US-20030096945-A1 | Well cement additives, compositions and methods | EOFF LARRY S (US) | 2003-05-22 | — | — | US | disclosed |
| US-20030094122-A1 | Well cement additives, compositions and methods | EOFF LARRY S (US) | 2003-05-22 | — | — | US | disclosed |
| US-6497283-B1 | CEMENTING USING SLURRY OF WATER, HYDRAULIC CEMENT AND FLUID LOSS CONTROL TERPOLYMER COMPRISING A VINYLSULFONIC ACID, 2-ALLYLOXY-2-HYDROXY-1-PROPANESULFONIC ACID OR 2-ACRYLAMIDO-2-METHYLPROPANESULFONIC ACID MONOMER | HALLIBURTON ENERGY SERVICES, INC. | 2002-12-24 | — | — | US | disclosed |