Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 16/20 | 0.49 |
| ▸ | CASP8 | Q14790 | 12/20 | 0.44 |
| ▸ | CASP6 | P55212 | 9/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 4/20 | 0.41 |
| ▸ | CASP7 | P55210 | 4/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5493968 | 0.86 | CASP3 (0.68) | CASP3CASP8CASP6CASP1CASP7 | |
| SCHEMBL8411027 | 0.78 | CASP1 (0.47) | CASP3CASP8CASP6CASP1 | |
| SCHEMBL6832898 | 0.77 | CASP3 (0.61) | CASP3CASP8CASP6CASP1CASP7 | |
| SCHEMBL6832897 | 0.77 | CASP3 (0.61) | CASP3CASP8CASP6CASP1CASP7 | |
| SCHEMBL6832920 | 0.76 | CASP3 (0.59) | CASP3CASP8CASP6CASP1CASP7 | |
| SCHEMBL7427132 | 0.76 | CASP1 (0.51) | CASP3CASP8CASP1CASP7 | |
| SCHEMBL7382193 | 0.76 | CYP2D6 (0.40) | CASP3CASP8CTSSCTSKCASP1 | |
| SCHEMBL10074125 | 0.76 | CASP3 (0.49) | CASP3CASP8CASP6CTSSCTSK | |
| SCHEMBL20471685 | 0.76 | CASP1 (0.51) | CASP3CASP8CASP1CASP7 | |
| SCHEMBL626800 | 0.76 | CASP3 (0.49) | CASP3CASP8CASP6CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480999-A2 | (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES | Idun Pharmaceuticals (US) | 2004-12-01 | — | — | EP | disclosed |
| US-20030232788-A1 | (Substituted)acyl dipeptidyl inhibitors of the ICE/ced-3 family of cysteine proteases | IDUN PHARMACEUTICALS, INC. | 2003-12-18 | — | — | US | disclosed |
| WO-2003072528-A2 | (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES | IDUN PHARMACEUTICALS, INC. (US) | 2003-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232788-A1 | (Substituted)acyl dipeptidyl inhibitors of the ICE/ced-3 family of cysteine proteases | DPP3, IAPP, CASP3 | CASP3 3/4885CASP8 38/4885CASP6 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.