Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6766970 | 0.84 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL12194930 | 0.81 | RELA (0.39) | CA12CA7CA9CA14ALDH1A1 | |
| SCHEMBL17771175 | 0.81 | ALDH1A1 (0.34) | CA12CA7CA9CA14ALDH1A1 | |
| SCHEMBL5547021 | 0.80 | MEN1 (0.36) | ALDH1A1 | |
| SCHEMBL9660903 | 0.79 | RELA (0.45) | CA12CA7CA14 | |
| SCHEMBL12137065 | 0.79 | CA12 (0.33) | CA12CA7CA9CA14ALDH1A1 | |
| SCHEMBL23905111 | 0.78 | RELA (0.47) | — | |
| SCHEMBL12194986 | 0.78 | RELA (0.47) | — | |
| SCHEMBL13398957 | 0.78 | RELA (0.47) | — | |
| SCHEMBL19996799 | 0.76 | CA12 (0.36) | CA12CA7CA9CA14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6743923-B2 | A BENZYLIDENE DERIVATIVES USED FOR OSTEOCLAST FORMATION INHIBITION, A NITROGEN MONOXIDE PRODUCTION INHIBITION, AND A TRANSCRIPTION FACTOR NF KAPPA B SUPRESSING AGENT | SHIONOGI & CO., LTD. (JP) | 2004-06-01 | — | — | US | disclosed |
| CN-1127492-C | Antirheumatic | SHIONOJI & CO LTD (JP) | 2003-11-12 | — | — | CN | disclosed |
| US-20030125364-A1 | Antirheumatic agent | MATSUMOTO SAICHI (JP) | 2003-07-03 | — | — | US | disclosed |
| US-6525081-B1 | Inhibiting osteoclast formation and nitrogen monoxide production; suppressing transcription factor NF kappa B | SHIONOGI & CO., LTD. (JP) | 2003-02-25 | — | — | US | disclosed |
| CN-1283194-A | Antirheumatic | SHIONOJI & CO LTD (JP) | 2001-02-07 | — | — | CN | disclosed |
| EP-1026162-A1 | ANTIRHEUMATIC | SHIONOGI & CO., LTD. (JP) | 2000-08-09 | — | — | EP | disclosed |
| CN-1035614-C | Benzylidene derivatives | SHIONOGI & CO (JP) | 1997-08-13 | — | — | CN | disclosed |
| EP-0595546-B1 | Benzylidene derivatives | SHIONOGI & CO (JP) | 1996-03-20 | — | — | EP | disclosed |
| US-5418230-A | Antiinflammatory | SHIONOGI & CO., LTD. (JP) | 1995-05-23 | — | — | US | disclosed |
| CN-1092414-A | Benzylidene derivatives | SHIONOGI & CO (JP) | 1994-09-21 | — | — | CN | disclosed |
| EP-0595546-A1 | Benzylidene derivatives | SHIONOGI & CO., LTD. (JP) | 1994-05-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030125364-A1 | Antirheumatic agent | IL1A, IL1B, IL17A | CA12 697/4885CA7 958/4885CA9 1615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.