SCHEMBL6833751

SCHEMBL6833751

FC(F)(F)c1ccc(-c2nc3c(C(F)(F)F)nc4ccccc4c3n2CCC2CCNCC2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACP1 P24666 3/20 0.38
TNKS O95271 1/20 0.38
WNT3A P56704 1/20 0.38
TNKS2 Q9H2K2 1/20 0.38
MEN1 O00255 1/20 0.37
POLB P06746 1/20 0.37
KMT2A Q03164 1/20 0.37
HTR6 P50406 1/20 0.37
NPY1R P25929 1/20 0.36
HTR4 Q13639 1/20 0.36
PARP1 P09874 1/20 0.35
PDE6D O43924 1/20 0.35
AVPR2 P30518 3/20 0.35
AVPR1A P37288 3/20 0.35
MCHR1 Q99705 1/20 0.34
TLR7 Q9NYK1 1/20 0.34
NR3C1 P04150 1/20 0.34
MERTK Q12866 1/20 0.34
KDM1A O60341 1/20 0.34
MAOB P27338 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6833713 0.94 NPY1R (0.39) ACP1NPY1RHTR4PDE6DAVPR2
SCHEMBL6838577 0.93 PDE6D (0.37) ACP1POLBKMT2ANPY1RHTR4
SCHEMBL6840049 0.93 ALDH1A1 (0.38) ACP1MEN1POLBKMT2ANPY1R
SCHEMBL7493132 0.92 ACP1 (0.38) ACP1MEN1POLBKMT2ANPY1R
SCHEMBL6840122 0.92 NPY1R (0.36) ACP1NPY1RHTR4PDE6DAVPR2
SCHEMBL6927038 0.91 ACP1 (0.38) ACP1TNKSWNT3ATNKS2MEN1
SCHEMBL6929042 0.90 NPY1R (0.40) ACP1TNKSWNT3ATNKS2MEN1
SCHEMBL6840139 0.90 ACP1 (0.38) ACP1NPY1RHTR4PDE6DTLR7
SCHEMBL6838389 0.89 ACP1 (0.46) ACP1MEN1KMT2ANPY1RHTR4
SCHEMBL6838696 0.89 NPY1R (0.40) ACP1NPY1RHTR4PDE6DAVPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040054182-A1 1h-imidazopyridine derivatives HOKURIKU SEIYAKU CO., LTD. (JP) 2004-03-18 US disclosed
EP-1256582-A1 1H-IMIDAZOPYRIDINE DERIVATIVES HOKURIKU SEIYAKU CO., LTD. (JP) 2002-11-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040054182-A1 1h-imidazopyridine derivatives IL2, IL1A, IL4 ACP1 490/4885TNKS 2446/4885WNT3A 3888/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.