SCHEMBL6840139

SCHEMBL6840139

FC(F)(F)c1nc2ccccc2c2c1nc(-c1ccccc1)n2CCC1CCNC1

nearest known ligand 0.38

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ACP1 P24666 14/20 0.38
PDE6D O43924 1/20 0.36
NPY1R P25929 2/20 0.35
TLR7 Q9NYK1 1/20 0.35
HTR4 Q13639 1/20 0.34
MERTK Q12866 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6833713 0.95 NPY1R (0.39) ACP1PDE6DNPY1RTLR7HTR4
SCHEMBL6840074 0.94 ACP1 (0.44) ACP1NPY1R
SCHEMBL6838577 0.90 PDE6D (0.37) ACP1PDE6DNPY1RTLR7HTR4
SCHEMBL6833751 0.90 ACP1 (0.38) ACP1PDE6DNPY1RTLR7HTR4
SCHEMBL6840049 0.90 ALDH1A1 (0.38) ACP1PDE6DNPY1RHTR4MERTK
SCHEMBL6838696 0.89 NPY1R (0.40) ACP1PDE6DNPY1RTLR7HTR4
SCHEMBL6840122 0.89 NPY1R (0.36) ACP1PDE6DNPY1RTLR7HTR4
SCHEMBL7493132 0.87 ACP1 (0.38) ACP1PDE6DNPY1RMERTK
SCHEMBL6838389 0.86 ACP1 (0.46) ACP1PDE6DNPY1RHTR4
SCHEMBL6833817 0.86 KHK (0.38) PDE6DNPY1RHTR4MERTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040054182-A1 1h-imidazopyridine derivatives HOKURIKU SEIYAKU CO., LTD. (JP) 2004-03-18 US disclosed
EP-1256582-A1 1H-IMIDAZOPYRIDINE DERIVATIVES HOKURIKU SEIYAKU CO., LTD. (JP) 2002-11-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040054182-A1 1h-imidazopyridine derivatives IL2, IL1A, IL4 ACP1 490/4885PDE6D 2316/4885NPY1R 1070/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.