SCHEMBL6834009

SCHEMBL6834009

N#Cc1ccc(NC(=O)c2cncc(-c3ccccc3C(F)(F)F)c2)c(C(=O)O)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSA P10619 1/20 0.47
ALDH1A1 P00352 1/20 0.43
KCNH2 Q12809 1/20 0.42
SCN10A Q9Y5Y9 1/20 0.42
KDM4E B2RXH2 2/20 0.42
MAPT P10636 2/20 0.42
SAE1 Q9UBE0 1/20 0.42
UBA2 Q9UBT2 1/20 0.42
TRPV1 Q8NER1 1/20 0.42
RXFP1 Q9HBX9 2/20 0.41
ALB P02768 2/20 0.41
DHODH Q02127 2/20 0.41
ABL1 P00519 1/20 0.41
SERPINE1 P05121 2/20 0.41
IGF2BP2 Q9Y6M1 1/20 0.40
XDH P47989 1/20 0.40
UBE2N P61088 1/20 0.40
KMT2A Q03164 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
SCN5A Q14524 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6835793 0.85 KCNH2 (0.49) CTSAALDH1A1KCNH2SCN10AALB
SCHEMBL6833755 0.85 KCNH2 (0.55) ALDH1A1KCNH2SCN10AKDM4EMAPT
SCHEMBL6833875 0.83 KDM4E (0.52) KCNH2SCN10AKDM4EMAPTSAE1
SCHEMBL6814812 0.83 KDM4E (0.46) CTSAKCNH2SCN10AKDM4EMAPT
SCHEMBL6833154 0.83 KDM4E (0.54) ALDH1A1KCNH2SCN10AKDM4EMAPT
SCHEMBL6833241 0.80 MAPK14 (0.47) ALDH1A1KCNH2SCN10AKDM4EMAPT
SCHEMBL6835718 0.80 SERPINE1 (0.50) ALDH1A1KCNH2SCN10AMAPTALB
SCHEMBL6819024 0.79 KMO (0.43) RXFP1ALBDHODHKMT2AACP1
SCHEMBL6920683 0.79 DHODH (0.41) ALDH1A1MAPTRXFP1ALBDHODH
SCHEMBL6834140 0.78 SCN10A (0.54) KCNH2SCN10AALBSERPINE1XDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040110802-A1 Antibacterial benzoic acid derivatives PHARMACIA & UPJOHN COMPANY 2004-06-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040110802-A1 Antibacterial benzoic acid derivatives GABRD, GABBR1, GABRA1 CTSA 306/4885ALDH1A1 170/4885KCNH2 1913/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.