SCHEMBL683483

SCHEMBL683483

O=C(O)[C@@H]1CC(O)CN1C(=O)CS

nearest known ligand 0.59

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.59
MME P08473 1/20 0.45
ACE P12821 3/20 0.41
VHL P40337 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7379358 1.00 ATM (0.59) ATMMMEACEVHL
SCHEMBL7374992 0.86 ATM (0.56) ATMMMEACE
SCHEMBL683107 0.86 ATM (0.56) ATMMMEACE
SCHEMBL6933806 0.83 ATM (0.61) ATMMMEACEVHL
SCHEMBL6933807 0.83 ATM (0.61) ATMMMEACEVHL
SCHEMBL1991504 0.83 ATM (0.61) ATMMMEACEVHL
SCHEMBL7378611 0.83 ATM (0.53) ATMMMEACE
SCHEMBL1334796 0.81 ATM (0.59) ATMMMEACEVHL
SCHEMBL1334899 0.81 ATM (0.59) ATMMMEACEVHL
SCHEMBL1334793 0.81 ATM (0.59) ATMMMEACEVHL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN BRAINCELLS INC. (US) 2011-11-03 US disclosed
US-20110046090-A1 MODULATION OF NEUROGENESIS WITH GABA AGENTS AND GABA ANALOGS BRAINCELLS INC. (US) 2011-02-24 US disclosed
US-20110046090-A1 MODULATION OF NEUROGENESIS WITH GABA AGENTS AND GABA ANALOGS BRAINCELLS INC. (US) 2011-02-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110046090-A1 MODULATION OF NEUROGENESIS WITH GABA AGENTS AND GABA ANALOGS GAP43, GABRB1, GABRB3 ATM 2176/4885MME 3258/4885ACE 4514/4885
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN NGF, DCX, BDNF ATM 3825/4885MME 50/4885ACE 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.