Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.69 |
| ▸ | HBB | P68871 | 1/20 | 0.69 |
| ▸ | P2RY6 | Q15077 | 4/20 | 0.65 |
| ▸ | P2RY14 | Q15391 | 4/20 | 0.65 |
| ▸ | NT5E | P21589 | 1/20 | 0.65 |
| ▸ | PYGM | P11217 | 3/20 | 0.61 |
| ▸ | TK2 | O00142 | 2/20 | 0.56 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.51 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7195413 | 0.92 | LMNA (0.66) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| SCHEMBL7195417 | 0.92 | LMNA (0.66) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| 5-Fluorouridine SCHEMBL1682759 | 0.90 | PYGM (0.70) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| 5-Fluorouridine SCHEMBL6891402 | 0.90 | PYGM (0.70) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| 5-Fluorouridine SCHEMBL19901621 | 0.90 | PYGM (0.70) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| 5-Fluorouridine SCHEMBL214536 | 0.90 | PYGM (0.70) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| 5-Fluorouridine SCHEMBL53091 | 0.90 | PYGM (0.70) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| 5-Fluorouridine SCHEMBL329747 | 0.90 | PYGM (0.70) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| 5-Fluorouridine SCHEMBL21423048 | 0.90 | PYGM (0.70) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| 5-Fluorouridine SCHEMBL2584234 | 0.90 | PYGM (0.70) | LMNASMN1; SMN2TSHRMAPTPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756496-B1 | SUCH AS TRIETHYLAMMONIUM-5'-DIMETHOXYTRITYL-3'-THYMIDINE-HYDROGEN PHOSPHONONDITHIOATE FOR USE AS ANTIVIRAL AND ANTICANCER AGENTS | ISIS PHARMACEUTICALS, INC. | 2004-06-29 | — | — | US | claimed |
| US-5565555-A | Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues | GILEAD SCIENCES, INC. (US) | 1996-10-15 | — | — | US | claimed |
| US-5194599-A | Forming linkages with nuclosides and nucleotides; viricides, anticarcinogenic agents | GILEAD SCIENCES, INC. (US) | 1993-03-16 | — | — | US | claimed |
| EP-0360609-A2 | Novel hydrogen phosphonodithioate compositions | GILEAD SCIENCES, INC. (US) | 1990-03-28 | — | — | EP | claimed |