Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GCG | P01275 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22410705 | 0.78 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2MAPTKDM4ERAB9A | |
| SCHEMBL4853400 | 0.78 | HTT (0.60) | ALDH1A1CYP2C19SMN1; SMN2MAPTKDM4E | |
| SCHEMBL13017491 | 0.77 | KDM4E (0.53) | ALDH1A1CYP1A2SMN1; SMN2MAPTKDM4E | |
| SCHEMBL4859824 | 0.71 | HTT (0.57) | ALDH1A1CYP2C19SMN1; SMN2MAPTKDM4E | |
| SCHEMBL6954161 | 0.70 | MAOB (0.56) | ALDH1A1CYP1A2SMN1; SMN2MAPTKDM4E | |
| SCHEMBL6965347 | 0.70 | SMN1; SMN2 (0.44) | ALDH1A1SMN1; SMN2MAPTKDM4ERAB9A | |
| SCHEMBL4859948 | 0.70 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2KDM4ERAB9AHPGD | |
| SCHEMBL6385943 | 0.70 | POLB (0.72) | ALDH1A1CYP1A2CYP2C19SMN1; SMN2MAPT | |
| SCHEMBL6602157 | 0.70 | CYP2C19 (0.56) | ALDH1A1CYP2C19SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL28193476 | 0.70 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2MAPTKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6815451-B2 | 1,2,3,4-Tetrahydroisoquinolines derivatives as urotensin II receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2004-11-09 | — | — | US | disclosed |
| US-20040110744-A1 | 1 2 3 4 Tetrahydroisoquinolines derivatives as urotensin II receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110744-A1 | 1 2 3 4 Tetrahydroisoquinolines derivatives as urotensin II receptor antagonists | UTS2R, NTSR2, NTSR1 | ALDH1A1 2575/4885CYP1A2 1235/4885CYP2C19 2350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.