Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | STAT3 | P40763 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | GCG | P01275 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22410705 | 0.84 | ALDH1A1 (0.53) | SMN1; SMN2MAPTRAB9AKDM4EALDH1A1 | |
| SCHEMBL6956521 | 0.83 | MAPT (0.42) | SMN1; SMN2MAPTRAB9AKDM4EALDH1A1 | |
| SCHEMBL13017491 | 0.79 | KDM4E (0.53) | SMN1; SMN2MAPTRAB9AKDM4EALDH1A1 | |
| SCHEMBL6954161 | 0.75 | MAOB (0.56) | SMN1; SMN2MAPTRAB9AKDM4EALDH1A1 | |
| SCHEMBL28193476 | 0.75 | ALDH1A1 (0.50) | SMN1; SMN2MAPTRAB9AKDM4EALDH1A1 | |
| SCHEMBL6962159 | 0.72 | L3MBTL1 (0.40) | SMN1; SMN2MAPTRAB9AKDM4EALDH1A1 | |
| SCHEMBL6835975 | 0.70 | ALDH1A1 (0.45) | SMN1; SMN2MAPTRAB9AKDM4EALDH1A1 | |
| SCHEMBL6965350 | 0.69 | GAA (0.44) | SMN1; SMN2MAPTRAB9AKDM4EALDH1A1 | |
| SCHEMBL6956204 | 0.69 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTRAB9AKDM4EALDH1A1 | |
| SCHEMBL17870665 | 0.69 | ALDH1A1 (0.50) | SMN1; SMN2MAPTRAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850222-B1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | SAMJIN PHARM CO LTD (KR) | 2003-05-28 | — | — | EP | disclosed |
| US-6028195-A | AN ANTITUMOR AGENT WITH VERY LOW TOXICITIES | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 2000-02-22 | — | — | US | disclosed |
| EP-0850222-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Samjin Pharmaceutical Co., Ltd. (KR) | 1998-07-01 | — | — | EP | disclosed |
| WO-1998000402-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 1998-01-08 | — | — | WO | disclosed |