SCHEMBL6839445

SCHEMBL6839445

N=C(N)c1ccc(N2CCN(C3CCN(CC(=O)O)CC3)CC2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 16/20 1.00
ITGA2B P08514 16/20 1.00
ALOX15 P16050 1/20 0.98
F2 P00734 2/20 0.54
PRSS1 P07477 2/20 0.54
PRSS2 P07478 2/20 0.54
PRSS3 P35030 2/20 0.54
TMPRSS6 Q8IU80 2/20 0.54
ST14 Q9Y5Y6 2/20 0.54
GRIN2D O15399 1/20 0.50
GRIN3B O60391 1/20 0.50
GRIN1 Q05586 1/20 0.50
GRIN2A Q12879 1/20 0.50
GRIN2B Q13224 1/20 0.50
GRIN2C Q14957 1/20 0.50
GRIN3A Q8TCU5 1/20 0.50
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8431411 0.98 ALOX15 (0.98) ITGB3ITGA2BALOX15F2PRSS1
Trifluoroacetic Acid SCHEMBL7334802 0.93 ITGB3 (0.87) ITGB3ITGA2BALOX15F2PRSS1
SCHEMBL7341889 0.86 ITGB3 (0.76) ITGB3ITGA2BALOX15F2PRSS1
SCHEMBL7343357 0.86 ITGB3 (0.75) ITGB3ITGA2BALOX15MEN1KMT2A
SCHEMBL7343348 0.86 ITGB3 (0.75) ITGB3ITGA2BALOX15MEN1KMT2A
SCHEMBL8034558 0.85 ITGB3 (0.74) ITGB3ITGA2BALOX15PRSS1PRSS2
SCHEMBL8784809 0.85 ITGB3 (0.73) ITGB3ITGA2BALOX15PRSS1PRSS2
SCHEMBL7344477 0.84 ITGB3 (0.72) ITGB3ITGA2BALOX15F2PRSS1
SCHEMBL27417535 0.84 ITGB3 (0.72) ITGB3ITGA2BALOX15F2PRSS1
SCHEMBL7345347 0.83 ITGB3 (0.71) ITGB3ITGA2BALOX15F2PRSS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240109979-A1 CELL ATTACHMENT MATERIALS, DEVICES AND USES THEREOF FACELLITATE GMBH (DE) 2024-04-04 US claimed
EP-4301788-A1 CELL ATTACHMENT MATERIALS, DEVICES AND USES THEREOF FaCellitate GmbH (DE) 2024-01-10 EP claimed
US-20230248771-A1 PLATELETS LOADED WITH ANTI-CANCER AGENTS CELLPHIRE, INC. (US) 2023-08-10 US claimed
WO-2022184899-A1 CELL ATTACHMENT MATERIALS, DEVICES AND USES THEREOF FACELLITATE GMBH (DE) 2022-09-09 WO claimed
EP-4053163-A1 CELL ATTACHMENT MATERIALS, DEVICES AND USES THEREOF FaCellitate GmbH (DE) 2022-09-07 EP claimed
US-6761856-B2 COAGULATION TIME TEST MEDTRONIC, INC. 2004-07-13 US claimed
US-20030211008-A1 Apparatus for determining platelet inhibitor response MEDTRONICS, INC. 2003-11-13 US claimed
US-6555066-B2 Multicell test apparatus, each cell contains an anticoagulant and a clotting activator, and at least one cell includes a platelet inactivating agent; platelet inhibition test MEDTRONIC, INC. 2003-04-29 US claimed
US-6555064-B2 Measuring blood coagulation time MEDTRONIC, INC. 2003-04-29 US claimed
US-6555381-B2 Mixing blood various amounts of activating factors, anticoagulants and platelet inhibitors; measuring clotting times MEDTRONIC, INC. 2003-04-29 US claimed
US-20010021355-A1 Method for determining platelet inhibitor response MEDTRONIC INC. 2001-09-13 US claimed
US-20010018215-A1 Method for determining platelet inhibitor response MEDTRONIC INC. 2001-08-30 US claimed
US-20010012634-A1 Method for determining platelet inhibitor response MEDTRONIC INC. 2001-08-09 US claimed
US-6221672-B1 DETERMINING DOSE RESPONSE BY PLACING HEPARIN, CONTACT ACTIVATOR, VARIOUS AMOUNTS OF PLATELET INACTIVATING AGENT INTO EACH CELL OF CARTRIDGE, ADDING BLOOD, MIXING, MEASURING CLOTTING TIME FOR EACH CELL, COMPUTING TIMES MEDTRONIC, INC. 2001-04-24 US claimed
US-6010911-A PLURALITY OF TEST CELLS; MIXTURE OF HEPARIN DEACTIVATING AGENT, ANTICOGULANTS AND CLOTTING COMPOUND MEDTRONIC, INC. (US) 2000-01-04 US claimed
WO-1998049563-A1 HEPARIN-INDEPENDENT, HIGH SENSITIVITY PLATELET FUNCTION EVALUATION TECHNIQUE MEDTRONIC, INC. (US) 1998-11-05 WO claimed
EP-0612313-A1 PIPERIDINE ACETIC ACID DERIVATIVES AS INHIBITORS OF FIBRINOGEN-DEPENDENT BLOOD PLATELET AGGREGATION GLAXO GROUP LIMITED (GB) 1994-08-31 EP claimed
CN-1090273-A Acetogenin GLAXO GROUP LTD (GB) 1994-08-03 CN claimed
WO-1993010091-A2 PIPERIDINE ACETIC ACID DERIVATIVES AS INHIBITORS OF FIBRINOGEN-DEPENDENT BLOOD PLATELET AGGREGATION GLAXO GROUP LIMITED (GB) 1993-05-27 WO claimed
EP-0542363-A2 Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation GLAXO GROUP LIMITED (GB) 1993-05-19 EP claimed