Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | DRD2 | P14416 | 2/20 | 0.62 |
| ▸ | DRD3 | P35462 | 2/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | BCHE | P06276 | 6/20 | 0.57 |
| ▸ | ACHE | P22303 | 6/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | BMP1 | P13497 | 1/20 | 0.55 |
| ▸ | MMP12 | P39900 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6837571 | 0.93 | KMT2A (0.76) | HDAC1HDAC2MEN1KMT2ADRD2 | |
| SCHEMBL6837896 | 0.86 | KMT2A (0.63) | HDAC1HDAC2MEN1KMT2ARXFP1 | |
| SCHEMBL31530557 | 0.81 | ADORA2A (0.61) | HDAC1HDAC2MEN1KMT2ADRD2 | |
| SCHEMBL6838023 | 0.80 | ALDH1A1 (0.48) | HDAC1HDAC2MEN1KMT2ANPC1 | |
| SCHEMBL5584871 | 0.79 | KMT2A (0.72) | HDAC1HDAC2MEN1KMT2ARXFP1 | |
| SCHEMBL6837907 | 0.79 | SLC6A5 (0.48) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6833294 | 0.78 | RAB9A (0.66) | HDAC1HDAC2MEN1KMT2ANPC1 | |
| SCHEMBL6833204 | 0.78 | SLC6A5 (0.52) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL5584565 | 0.77 | RAB9A (0.72) | HDAC1HDAC2MEN1KMT2ARXFP1 | |
| SCHEMBL2979270 | 0.77 | BCHE (0.57) | HDAC1HDAC2DRD2DRD3RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716987-B1 | PHOSPHODIESTERASE IV INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2004-04-06 | — | — | US | disclosed |
| US-6514996-B2 | Derivatives of benzofuran or benzodioxole | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2003-02-04 | — | — | US | disclosed |