Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 17/20 | 0.66 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.62 |
| ▸ | PPARG | P37231 | 1/20 | 0.62 |
| ▸ | HTR2B | P41595 | 1/20 | 0.62 |
| ▸ | PPARD | Q03181 | 1/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6839834 | 0.95 | ADORA3 (0.68) | ADORA3ADORA1ADORA2AHTR2CPPARG | |
| Acetic Acid SCHEMBL6839833 | 0.91 | ADORA3 (0.69) | ADORA3ADORA1ADORA2AHTR2CPPARG | |
| SCHEMBL6841735 | 0.82 | ADORA3 (0.51) | ADORA3ADORA1ADORA2AHTR2CPPARG | |
| SCHEMBL6839134 | 0.81 | ADORA3 (0.60) | ADORA3ADORA1ADORA2AHTR2CPPARG | |
| SCHEMBL24601182 | 0.79 | ADORA3 (0.78) | ADORA3ADORA1ADORA2AHTR2CPPARG | |
| Formic Acid SCHEMBL6841731 | 0.79 | ADORA3 (0.56) | ADORA3ADORA1ADORA2AHTR2CPPARG | |
| SCHEMBL6838896 | 0.79 | NT5E (0.41) | ADORA3ADORA1ADORA2ATP53MAPT | |
| SCHEMBL6841733 | 0.78 | ADORA3 (0.49) | ADORA3ADORA1ADORA2AHTR2CPPARG | |
| SCHEMBL6838893 | 0.78 | ADORA1 (0.58) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL6841630 | 0.77 | ALDH1A1 (0.40) | ADORA3ADORA1ADORA2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6762170-B1 | ANTIINFLAMMATORY AGENTS INHIBIT LEUKOCYTE RECRUITMENT AND ACTIVATION AND ARE AGONISTS OF THE ADENOSINE 2A RECEPTOR; PENDANT ISOXAZOLE; REACTING A 2,6-DIAMINOPURINE WITH A 2-(3-SUBSTITUTED ISOXAZOL-5-YL)TETRAHYDROFURAN-3,4-DIOL | SMITHKLINEBEECHAM CORPORATION | 2004-07-13 | — | — | US | disclosed |
| EP-1051425-A2 | 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999038877-A2 | 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-08-05 | — | — | WO | disclosed |