Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 3/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300491 | 0.81 | ALOX15 (0.41) | NPC1RAB9AHTTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9200760 | 0.79 | ALOX15 (0.39) | NPC1RAB9AHTT | |
| SCHEMBL311710 | 0.79 | BCHE (0.42) | NPC1RAB9AHTTHRH3MEN1 | |
| Hydrochloric Acid SCHEMBL29375122 | 0.78 | BCHE (0.41) | NPC1RAB9AHTTHRH3MEN1 | |
| SCHEMBL3096843 | 0.78 | KDM4E (0.48) | HTR6HRH3HTR3A | |
| SCHEMBL6904489 | 0.76 | TP53 (0.45) | HTTMEN1GAAKMT2APIM1 | |
| SCHEMBL4456263 | 0.76 | KDM4E (0.47) | HTR6HRH3HTR3A | |
| SCHEMBL21047581 | 0.74 | HIPK2 (0.42) | — | |
| SCHEMBL5237091 | 0.74 | HRH4 (0.47) | HRH4HTTHTR6HTR3A | |
| SCHEMBL6281359 | 0.73 | AKT2 (0.49) | HRH3MEN1KMT2AHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021050913-A1 | INHIBITORS OF SARM1 | DISARM THERAPEUTICS, INC. (US) | 2021-03-18 | — | — | WO | disclosed |
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |