Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300491 | 0.81 | ALOX15 (0.41) | TP53JAK3MAPK1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9200760 | 0.79 | ALOX15 (0.39) | TP53JAK3MAPK1HTTSMN1; SMN2 | |
| SCHEMBL311710 | 0.79 | BCHE (0.42) | TP53JAK3MAPK1HTTSMN1; SMN2 | |
| SCHEMBL3096843 | 0.78 | KDM4E (0.48) | ALOX15KDM4E | |
| Hydrochloric Acid SCHEMBL29375122 | 0.78 | BCHE (0.41) | TP53JAK3HTTSMN1; SMN2MEN1 | |
| SCHEMBL4456263 | 0.76 | KDM4E (0.47) | KDM4E | |
| SCHEMBL6840293 | 0.76 | NPC1 (0.41) | HTTPIM1MEN1KMT2AGAA | |
| SCHEMBL21047581 | 0.74 | HIPK2 (0.42) | SMN1; SMN2ALOX15LMNAHIPK2 | |
| SCHEMBL14858605 | 0.74 | LMNA (0.47) | JAK3POLBCHEK1PDPK1MAPK1 | |
| SCHEMBL6281359 | 0.73 | AKT2 (0.49) | CHEK1MEN1TSHRKMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663416-A | ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS OR DERMATITIS TREATMENT | CORTECH INC. | 1997-09-02 | — | — | US | claimed |
| WO-2021114091-A1 | HOMOGENEOUS CATALYST AND HETEROGENEOUS CATALYST BASED ON IONIC LIQUID, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 沈阳化工大学 | 2021-06-17 | — | — | WO | disclosed |
| CN-111804331-A | Homogeneous catalyst and heterogeneous catalyst based on ionic liquid, and preparation method and application thereof | 沈阳化工大学 | 2020-10-23 | — | — | CN | disclosed |
| US-10005774-B2 | Syk inhibitors | GILEAD SCIENCES, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| EP-3027601-B1 | SYK INHIBITORS | GILEAD SCIENCES INC (US) | 2017-10-25 | — | — | EP | disclosed |
| US-20160368918-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2016-12-22 | — | — | US | disclosed |
| US-9376441-B2 | Substituted pyrrolidines as SYK inhibitors | GILEAD SCIENCES, INC. (US) | 2016-06-28 | — | — | US | disclosed |
| EP-3027601-A1 | SYK INHIBITORS | Gilead Sciences, Inc. (US) | 2016-06-08 | — | — | EP | disclosed |
| WO-2015017610-A1 | SYK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2015-02-05 | — | — | WO | disclosed |
| US-20150038488-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2015-02-05 | — | — | US | disclosed |
| US-20140221374-A1 | RAF KINASE INHIBITORS | RUGA CORPORATION (US) | 2014-08-07 | — | — | US | disclosed |
| WO-2012125981-A2 | RAF KINASE INHIBITORS | SELEXAGEN THERAPEUTICS, INC. (US) | 2012-09-20 | — | — | WO | disclosed |
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |
| US-6743937-B2 | WATER SOLUBILITY; ANGIOGENESIS INHIBITOR, ANTICANCER AGENTS | OXIGENE, INC. | 2004-06-01 | — | — | US | disclosed |
| WO-1995003998-A1 | WATER CONTROL SYSTEM USING OXIDATION REDUCTION POTENTIAL SENSING | H.E.R.C. PRODUCTS INCORPORATED (US) | 1995-02-09 | — | — | WO | disclosed |
| US-5342510-A | Automatically controlling scale | H.E.R.C. INCORPORATED (US) | 1994-08-30 | — | — | US | disclosed |
| US-5332494-A | Amine or ammonium salt of mineral acid | H.E.R.C. INCORPORATED (US) | 1994-07-26 | — | — | US | disclosed |
| US-3968099-A | Process for the preparation of azo dyestuffs containing cyano groups | BAYER AKTIENGESELLSCHAFT (DT) | 1976-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221374-A1 | RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | TP53 75/4885JAK3 411/4885POLB 1383/4885 |
| US-20150038488-A1 | SYK INHIBITORS | SYK, BTK, LYN | TP53 130/4885JAK3 26/4885POLB 3881/4885 |
| US-20160368918-A1 | SYK INHIBITORS | SYK, BTK, LYN | TP53 133/4885JAK3 24/4885POLB 3783/4885 |
| US-10005774-B2 | Syk inhibitors | SYK, BTK, LYN | TP53 133/4885JAK3 24/4885POLB 3783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.