Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 10/20 | 0.53 |
| ▸ | HTR1B | P28222 | 8/20 | 0.53 |
| ▸ | HTR2A | P28223 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.53 |
| ▸ | HTR3B | O95264 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31415380 | 0.82 | CA12 (0.47) | MAPTTP53MAPK1RAB9AHPGD | |
| SCHEMBL8268112 | 0.82 | MAPT (0.60) | MAPTTP53MAPK1RAB9AHPGD | |
| SCHEMBL5465792 | 0.76 | PLK1 (0.52) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL6926831 | 0.75 | PLK1 (0.51) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL7445617 | 0.75 | PLK1 (0.51) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL408034 | 0.75 | CYP17A1 (0.46) | KDM4EPSMB8CYP17A1HDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL38666104 | 0.74 | HTR1D (0.52) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL2700980 | 0.74 | HDAC4 (0.61) | HDAC1HDAC8 | |
| SCHEMBL38665653 | 0.73 | L3MBTL1 (0.65) | HTR1DMAPTMEN1KMT2ATDP1 | |
| SCHEMBL203019 | 0.73 | CYP17A1 (0.49) | MAPTMEN1KMT2ATP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040132720-A1 | Piperazine derivatives, their preparation and uses in therapy (5ht1b receptor activity) | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132720-A1 | Piperazine derivatives, their preparation and uses in therapy (5ht1b receptor activity) | SIGMAR1, HTR6, OPRL1 | HTR1D 44/4885HTR1B 7/4885HTR2A 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.