Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.33 |
| ▸ | STK4 | Q13043 | 1/20 | 0.33 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6844424 | 0.91 | CYP11B2 (0.35) | RPS6KA3STK4SOSTROCK2 | |
| SCHEMBL6840386 | 0.85 | STK4 (0.34) | RPS6KA3STK4 | |
| SCHEMBL6844502 | 0.84 | STK4 (0.37) | RPS6KA3STK4 | |
| SCHEMBL6844422 | 0.83 | STK4 (0.36) | RPS6KA3STK4 | |
| SCHEMBL12452347 | 0.80 | PLK1 (0.50) | — | |
| SCHEMBL6840522 | 0.79 | USP1 (0.35) | RPS6KA3STK4 | |
| SCHEMBL6840403 | 0.78 | STK4 (0.38) | RPS6KA3STK4 | |
| SCHEMBL12451842 | 0.75 | PLK1 (0.52) | RPS6KA3 | |
| SCHEMBL6844466 | 0.73 | PLK1 (0.48) | — | |
| SCHEMBL2341484 | 0.71 | PLK1 (0.51) | STK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516441-B1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARM INC (US) | 2015-01-21 | — | — | EP | disclosed |
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |