Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 6/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.48 |
| ▸ | PYGL | P06737 | 7/20 | 0.43 |
| ▸ | PYGM | P11217 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6753481 | 1.00 | F10 (0.51) | F10ALOX15PYGLPYGMF2 | |
| SCHEMBL6840928 | 0.89 | GHSR (0.41) | F10 | |
| SCHEMBL6839437 | 0.89 | DRD4 (0.50) | F10ALOX15PYGLPYGM | |
| SCHEMBL5260262 | 0.83 | F10 (0.59) | F10ALOX15PYGLPYGMF2 | |
| SCHEMBL6839255 | 0.82 | PYGL (0.44) | PYGLPYGMSMYD3 | |
| SCHEMBL6386370 | 0.82 | TAS1R3 (0.49) | F10 | |
| SCHEMBL6386374 | 0.82 | TAS1R3 (0.49) | F10 | |
| SCHEMBL6380975 | 0.80 | TAS1R3 (0.61) | — | |
| SCHEMBL6380972 | 0.80 | TAS1R3 (0.61) | — | |
| SCHEMBL16842006 | 0.79 | TAS1R3 (0.59) | F10ALOX15PYGLPYGMF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6759428-B2 | SUCH AS N-((1,2)-2-(((CYANO(CYCLOPROPYL)METHYL)AMINO)CARBONYL) CYCLOHEXYL)-1H-INDOLE-2-CARBOXAMIDE; CATHEPSIN K INHIBITORS | ROCHE PALO ALTO LLC | 2004-07-06 | — | — | US | disclosed |