Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | NTSR2 | O95665 | 8/20 | 0.34 |
| ▸ | NTSR1 | P30989 | 5/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | NPY4R | P50391 | 1/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL6246869 | 0.97 | ITGB3 (0.37) | ITGB3ITGA2BNTSR2NTSR1SORT1 | |
| Tyrosine SCHEMBL6246872 | 0.84 | OPRM1 (0.37) | NTSR2NTSR1SORT1THRBSLC7A5 | |
| Lysine SCHEMBL15972445 | 0.79 | THRB (0.35) | ITGB3ITGA2BNTSR2NTSR1SORT1 | |
| Tyrosine SCHEMBL28702925 | 0.79 | NTSR2 (0.36) | NTSR2NTSR1SORT1THRBSLC7A5 | |
| Tyrosine SCHEMBL9282617 | 0.79 | SLC7A5 (0.44) | ITGB3ITGA2BNTSR2NTSR1SORT1 | |
| Tyrosine SCHEMBL9282615 | 0.79 | SLC7A5 (0.44) | ITGB3ITGA2BNTSR2NTSR1SORT1 | |
| Glutamine SCHEMBL10424734 | 0.79 | — | — | |
| Lysine SCHEMBL15972073 | 0.78 | ITGB3 (0.36) | ITGB3ITGA2BTHRBGHSR | |
| Tyrosine SCHEMBL28209384 | 0.78 | SLC7A5 (0.41) | ITGB3ITGA2BTHRBLNPEPSLC7A5 | |
| Threonine SCHEMBL9058511 | 0.77 | SLC7A5 (0.36) | ITGB3ITGA2BSLC7A5REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040175813-A1 | Mutant P53 proteins and uses thereof | KLINE KIMBERLY (US) | 2004-09-09 | — | — | US | disclosed |