Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12956833 | 0.74 | NPSR1 (0.70) | NPSR1ALDH1A1HPGDL3MBTL1MCL1 | |
| SCHEMBL1101441 | 0.68 | NPSR1 (0.41) | NPSR1ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL14123168 | 0.67 | NPSR1 (0.47) | NPSR1ALDH1A1HPGDL3MBTL1MCL1 | |
| SCHEMBL1101374 | 0.67 | NPSR1 (0.40) | NPSR1ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL7587289 | 0.66 | CHEK1 (0.39) | ALDH1A1HPGDL3MBTL1CHEK1AURKA | |
| SCHEMBL170250 | 0.66 | NPSR1 (0.36) | NPSR1IMPDH2 | |
| SCHEMBL28323788 | 0.65 | NPSR1 (0.39) | NPSR1ALDH1A1HPGDIMPDH2KDM4E | |
| SCHEMBL9398319 | 0.65 | MAPT (0.36) | NPSR1ALDH1A1HPGDKDM4E | |
| Hydrochloric Acid SCHEMBL8723152 | 0.65 | CHEK1 (0.38) | ALDH1A1HPGDL3MBTL1CHEK1AURKA | |
| SCHEMBL10169133 | 0.64 | NPSR1 (0.66) | NPSR1ALDH1A1HPGDL3MBTL1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6683166-B2 | RESISTANT TO NUCLEASES, ENHANCED ABILITY TO PENETRATE CELLS, AND CAPABLE OF BINDING TARGET OLIGONUCLEOTIDE SEQUENCES IN VITRO AND VIVO | ISIS PHARMACEUTICALS, INC. | 2004-01-27 | — | — | US | disclosed |
| US-20030120050-A1 | Modified internucleoside linkages (ii) | SWAMINATHAN SUNDARAMOORTHI (US) | 2003-06-26 | — | — | US | disclosed |
| US-6410702-B1 | OLIGONUCLEOTIDE; FOR USE IN THE HUMAN THERAPEUTICS AND DIAGNOSTICS | ISIS PHARMACEUTICALS, INC. | 2002-06-25 | — | — | US | disclosed |
| US-5817781-A | ENZYME INHIBITORS; INCREASED PENETRATION OF CELLS; DEACTIVATEPROTEIN SYNTHESIS, RNA, DNA | GILEAD SCIENCES, INC. (US) | 1998-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030120050-A1 | Modified internucleoside linkages (ii) | POLRMT, NSUN2, POLR2E | NPSR1 3836/4885ALDH1A1 4128/4885HPGD 4279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.