SCHEMBL684286

SCHEMBL684286

COc1cccc(CC(C)NCCn2cnc3c2c(=O)n(C)c(=O)n3C)c1OC

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 5/20 0.52
KDM4E B2RXH2 1/20 0.52
ALOX15 P16050 1/20 0.51
SMN1; SMN2 Q16637 3/20 0.48
CASP1 P29466 1/20 0.48
TP53 P04637 1/20 0.47
LMNA P02545 2/20 0.47
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
ALDH1A1 P00352 1/20 0.45
MAPK1 P28482 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
ADORA2B P29275 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL683985 0.92 ALOX15 (0.56) RXFP1ALOX15SMN1; SMN2CASP1TP53
SCHEMBL683986 0.84 CYP1A2 (0.51) RXFP1ALOX15SMN1; SMN2TP53LMNA
SCHEMBL683913 0.83 RXFP1 (0.55) RXFP1KDM4EALOX15SMN1; SMN2TP53
SCHEMBL25395304 0.81 RXFP1 (0.57) RXFP1ALOX15SMN1; SMN2LMNAMEN1
SCHEMBL683922 0.81 CYP1A2 (0.61) RXFP1ALOX15SMN1; SMN2TP53LMNA
SCHEMBL683921 0.80 RXFP1 (0.68) RXFP1KDM4ESMN1; SMN2TP53LMNA
SCHEMBL683984 0.80 RXFP1 (0.63) RXFP1KDM4ESMN1; SMN2TP53LMNA
Fenethylline SCHEMBL149145 0.79 ALDH1A1 (0.65) RXFP1SMN1; SMN2LMNAALDH1A1MAPK1
Fenethylline SCHEMBL121386 0.78 ALDH1A1 (0.64) RXFP1SMN1; SMN2LMNAALDH1A1MAPK1
Fenethylline SCHEMBL155920 0.78 ALDH1A1 (0.64) RXFP1SMN1; SMN2LMNAALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN BRAINCELLS INC. (US) 2011-11-03 US disclosed
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN BRAINCELLS INC. (US) 2011-11-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN NGF, DCX, BDNF RXFP1 211/4885KDM4E 2527/4885ALOX15 1046/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.