Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 4/20 | 0.42 |
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13911864 | 0.89 | NPC1 (0.57) | NPC1RAB9AMAPTSMN1; SMN2GFER | |
| SCHEMBL14684135 | 0.80 | MAOA (0.67) | NPC1RAB9AMAPTSMN1; SMN2GFER | |
| SCHEMBL1796025 | 0.80 | MAOA (0.67) | NPC1RAB9AMAPTSMN1; SMN2GFER | |
| Hydrochloric Acid SCHEMBL3367899 | 0.79 | MAOA (0.64) | NPC1RAB9AMAPTSMN1; SMN2GFER | |
| SCHEMBL2000388 | 0.79 | PIM1 (0.49) | NPC1RAB9AMAPTSMN1; SMN2GFER | |
| SCHEMBL1421334 | 0.76 | APP (0.46) | NPC1RAB9AMAPTSMN1; SMN2GFER | |
| SCHEMBL10123835 | 0.76 | AHR (0.41) | NPC1RAB9AMAPTSMN1; SMN2GFER | |
| SCHEMBL24688956 | 0.75 | ALDH1A1 (0.81) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL14684134 | 0.75 | PON1 (0.49) | NPC1RAB9AMAPTSMN1; SMN2GFER | |
| SCHEMBL10170969 | 0.75 | CYP11B1 (0.44) | NPC1RAB9AMAPTSMN1; SMN2GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |